Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/151093
Title: MOLECULAR CHARACTERIZATION OF GREB1 AND TRAF3 IN THE ONCOGENIC SIGNALLING PATHWAYS OF HUMAN CANCER
Authors: SULTAN ABDA NEJA
Keywords: Breast Cancer, GREB1, Multiple Myeloma, NF-kB, TRAF3
Issue Date: 6-Aug-2018
Citation: SULTAN ABDA NEJA (2018-08-06). MOLECULAR CHARACTERIZATION OF GREB1 AND TRAF3 IN THE ONCOGENIC SIGNALLING PATHWAYS OF HUMAN CANCER. ScholarBank@NUS Repository.
Abstract: Deregulation of cell signalling pathwaysthat control growth and cell fate is one of the most important hallmarks of human cancer.NF-κBpathwaydysregulationis critical for the pathogenesis of human cancers. Mutation of TRAF3; an upstream adapter molecule constitutively activatesthis pathwayinMultiple Myeloma. I found TRAF3 mutation underliesthe de-novo survival andthe acquisition of proteasome inhibitor resistance (PIR). I identified key players in the mechanism of PIR.ER+ breast cancer also uses ERαto sustain proliferative signalling. Growth regulation by Estrogen in Breast Cancer 1 (GREB1) is one of the top E2 responsive ERα target genes. Loss of GREB1 results in cell proliferation defects by attenuating ER signalling. However, the molecular mechanism by which GREB1 affects ER-associated tumor growth is barely known. I identified GREB1 is a novel glycosyltransferase enzyme which glycosylates and stabilizes ERα and subsequently promotestumor growth. Loss of GREB1 confers tamoxifen resistance.
URI: http://scholarbank.nus.edu.sg/handle/10635/151093
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