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Title: Folk medicine- Cratoxylum cochinchinense: Antioxidant but cytotoxic
Keywords: Oxidative stress, free radical, cratoxylum cochinchinense, mangiferin, folk medicine, plasma membrane redox system
Issue Date: 9-Jan-2006
Citation: TANG SOON YEW (2006-01-09). Folk medicine- Cratoxylum cochinchinense: Antioxidant but cytotoxic. ScholarBank@NUS Repository.
Abstract: There is a lot of interest in natural products as the quest for more active and novel antioxidant ingredients continues. TCM make-up a significant proportion of the total consumption of herbal medicine around the world. They are rich sources of phenolic compounds and these phenolic compounds may be related to their alleged antioxidant effects. Therefore, we first tested the hypothesis that TCM (available from local medicinal shops) possess strong antioxidant activities as characterize using various established and reliable antioxidant-based assays. We also attempted to identify the constituents that may be responsible for the antioxidant activities from Cratoxylum cochinchinense which outperformed other TCM extracts. C. cochinchinense is a small genus of Southeast Asian trees belonging to the Guttiferae family. It is used in traditional medicine for many purposes. However, many health claims pertaining to C. cochinchinense are not supported by scientific studies and are myths that passed down from previous generations. Triterpenoids, tocotrienols and xanthones are some of the constituents in the bark of C. cochinchinense. However, there has been limited research on the biological properties of C. cochinchinense extract and its isolated constituents. Therefore, we examined the effects of C. cochinchinense extract (YCT), which contains largely mangiferin, on a range of cell types to test whether a potent antioxidant also posseses cytoprotective effect. We are also interested to find out the modes of action of YCT extract-induced cell death in Jurkat T cells.
Appears in Collections:Ph.D Theses (Open)

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