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Title: Development of novel drug delivery system - Lipid microemulsion of tributyrin
Authors: SU JIE
Keywords: Tributyrin, Lipid submicro-emulsion, Lipoprotein, Pharmacokinetics, Carcinoma cells, ATRA
Issue Date: 22-Feb-2006
Citation: SU JIE (2006-02-22). Development of novel drug delivery system - Lipid microemulsion of tributyrin. ScholarBank@NUS Repository.
Abstract: Tributyrin has been shown to be an effective anti-tumor agent alone or in combination with other chemotherapeutic agents in vitro. As a triglyceride-typed oil, tributyrin could be formulated as an emulsion to facilitate its delivery. The aim of this project was to develop a lipid submicro-emulsion of tributyrin with affinity to low-density lipoprotein (LDL) or apolipoprotein(s) and evaluate its in vitro cellular activity and in vivo pharmacokinetic properties. The emulsion monolayer prepared was proved to bind effectively with LDL and apolipoprotein(s) in vitro. In vivo, the pharmacokinetic properties of tributyrin were changed after incorporated into emulsion due to uptake via the LDL-receptor mediated pathway. The selective uptake by the cellular LDL receptors was further confirmed by testing the cellular viability in the presence of competing LDL. The tributyrin emulsion was used as a carrier for ATRA, and studies were conducted and proved to enhance the drug effect by reducing the clearance and increasing the in vitro activity.
Appears in Collections:Ph.D Theses (Open)

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