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Title: Syntheses, structures and properties of novel poly(amino ester)s
Keywords: Michael addition polymerization, poly(amino ester)s, non-viral gene vectors, gene delivery, fluorescence, biodegradable
Issue Date: 9-Jan-2006
Citation: WU DECHENG (2006-01-09). Syntheses, structures and properties of novel poly(amino ester)s. ScholarBank@NUS Repository.
Abstract: pH-Sensitivity, biodegradability and biocompatibility make poly(amino ester)s promising materials for biotechnology. But so far, the chemistry of poly(amino ester)s reported is very limited, especially in amine constitution. Hence novel kinds of poly(amino ester)s are desirable. In our works, firstly the mechanisms of the Michael addition polymerization of trifunctional amines and diacrylates or triacrylates were clearly clarified. Based on the results, we designed and synthesized two novel kinds of poly(amino ester)s, i.e., linear poly(amino ester)s with secondary and tertiary amines in their backbones and hyperbranched poly(amino ester)s with diversiform combination of primary, secondary and tertiary amines. Some poly(amino ester)s were demonstrated to show low cytotoxicity and good transfection efficiency for DNA delivery comparable to polyethylenimine (PEI). Furthermore, some hyperbranched poly(amino ester)s can emit blue fluorescence. These poly(amino ester)s should be applicable for safe and efficient gene and drug delivery and as novel biocompatible fluorophores.
Appears in Collections:Ph.D Theses (Open)

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