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Title: Tissue engineering approach to anterior cruciate ligament reconstruction
Authors: GE ZIGANG
Keywords: anterior cruciate ligament, tissue engineering, biomaterials, scaffold,
Issue Date: 13-Feb-2006
Citation: GE ZIGANG (2006-02-13). Tissue engineering approach to anterior cruciate ligament reconstruction. ScholarBank@NUS Repository.
Abstract: Anterior cruciate ligament (ACL) injuries may result in significant disability if left untreated. Tissue engineered anterior cruciate ligaments have the potential to overcome drawbacks from current therapies. We Hypothesize that knitted biphasic scaffolds can provide enough mechanical strength before ligament regeneration and that seeding of mesenchymal stem cells (MSCs) and fascia wrap can promote anterior cruciate ligament regeneration. Methods: Current research consists of three stages, firstly, to select the optimal cell source for ACL tissue engineering; secondly, to design and characterize the knitted scaffolds for ACL tissue engineering; and lastly, to test in vivo effects of knitted scaffolds in a rabbit model as well as to evaluate effects of MSC seeding and fascia wrap application. Conclusion: MSCs are optimal seeding cell source. Current knitted scaffolds are suitable for potential tissue engineered ACLs. Both MSC seeding and fascia wraps can promote more collagen formation, while fascia wrap shows stronger effects than MSC seeding. Both MSC seeding and fascia wrap could not enhance ultimate tensile load and stiffness.
Appears in Collections:Ph.D Theses (Open)

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