Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0181077
Title: Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance
Authors: Vassiliou V.S.
Flynn P.D.
Raphael C.E.
Newsome S.
Khan T.
Ali A.
Halliday B.
Bruengger A.S.
Malley T.
Sharma P.
Selvendran S.
Aggarwal N.
Sri A.
Berry H.
Donovan J.
Lam W.
Auger D.
Cook S.A. 
Pennell D.J.
Prasad S.K.
Issue Date: 2017
Publisher: Public Library of Science
Citation: Vassiliou V.S., Flynn P.D., Raphael C.E., Newsome S., Khan T., Ali A., Halliday B., Bruengger A.S., Malley T., Sharma P., Selvendran S., Aggarwal N., Sri A., Berry H., Donovan J., Lam W., Auger D., Cook S.A., Pennell D.J., Prasad S.K. (2017). Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance. PLoS ONE 12 (7) : e0181077. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0181077
Abstract: Background Aortic stenosis is the most common age-related valvular pathology. Patients with aortic stenosis and myocardial fibrosis have worse outcome but the underlying mechanism is unclear. Lipoprotein(a) is associated with adverse cardiovascular risk and is elevated in patients with aortic stenosis. Although mechanistic pathways could link Lipoprotein(a) with myocardial fibrosis, whether the two are related has not been previously explored. In this study, we investigated whether elevated Lipoprotein(a) was associated with the presence of myocardial replacement fibrosis. Methods A total of 110 patients with mild, moderate and severe aortic stenosis were assessed by late gadolinium enhancement (LGE) cardiovascular magnetic resonance to identify fibrosis. Mann Whitney U tests were used to assess for evidence of an association between Lp(a) and the presence or absence of myocardial fibrosis and aortic stenosis severity and compared to controls. Univariable and multivariable linear regression analysis were undertaken to identify possible predictors of Lp(a). Results Thirty-six patients (32.7%) had no LGE enhancement, 38 (34.6%) had midwall enhancement suggestive of midwall fibrosis and 36 (32.7%) patients had subendocardial myocardial fibrosis, typical of infarction. The aortic stenosis patients had higher Lp(a) values than controls, however, there was no significant difference between the Lp(a) level in mild, moderate or severe aortic stenosis. No association was observed between midwall or infarction pattern fibrosis and Lipoprotein(a), in the mild/moderate stenosis (p = 0.91) or severe stenosis patients (p = 0.42). Conclusion There is no evidence to suggest that higher Lipoprotein(a) leads to increased myocardial midwall or infarction pattern fibrosis in patients with aortic stenosis. © 2017 Vassiliou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/150634
ISSN: 19326203
DOI: 10.1371/journal.pone.0181077
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
journal.pone.0181077.pdf8.02 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

2
checked on Sep 21, 2020

WEB OF SCIENCETM
Citations

3
checked on Jul 17, 2019

Page view(s)

135
checked on Sep 18, 2020

Download(s)

18
checked on Sep 18, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.