Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/150360
Title: A STUDY OF FREEZE-DRIED CUSHIONING EXCIPIENTS IN COMPACTED MULTIPLE-UNIT PELLET SYSTEMS
Authors: SIOW RU SHAN CARIN
Keywords: mannitol-hydroxypropylmethylcellulose, freeze-drying, co-processed excipient, cushioning excipient, MUPS, multivariate analysis
Issue Date: 20-Aug-2018
Citation: SIOW RU SHAN CARIN (2018-08-20). A STUDY OF FREEZE-DRIED CUSHIONING EXCIPIENTS IN COMPACTED MULTIPLE-UNIT PELLET SYSTEMS. ScholarBank@NUS Repository.
Abstract: Preparation of multiple-unit pellet system tablets is a challenge as the compaction force exerted during tableting may damage the pellet coat, thereby altering drug release rates. Thus, cushioning excipients by bulk freeze-drying cum milling was explored. It was demonstrated that bulk freeze-drying-milling could be employed to develop porous and directly compressible particulates as cushioning excipients. Mannitol-HPMC formulations were selected for further studies and it was found that the formulation variables (HPMC viscosity grades, mannitol:HPMC ratio, excipient size fraction) and freeze-drying conditions (solid content, shelf temperature-lowering rate) influenced the physical properties of the freeze-dried excipients. These have a bearing on the cushioning performance and resultant tablet properties. Overall, the results provided an insight on the characteristics of freeze-dried materials and the desired physicomechanical properties for effective cushioning function to prevent pellet coat damage during tableting.
URI: http://scholarbank.nus.edu.sg/handle/10635/150360
Appears in Collections:Ph.D Theses (Open)

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