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Title: Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity
Authors: Tan E.-K. 
Tan C.
Zhao Y.
Yew K.
Shen H.
Chandran V.R.
Teoh M.-L.
Yih Y.
Pavanni R. 
Wong M.-C. 
Keywords: DJ-1
Parkinson's disease
Issue Date: 2004
Publisher: Elsevier
Citation: Tan E.-K., Tan C., Zhao Y., Yew K., Shen H., Chandran V.R., Teoh M.-L., Yih Y., Pavanni R., Wong M.-C. (2004). Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity. Neuroscience Letters 367 (1) : 109-112. ScholarBank@NUS Repository.
Abstract: Mutations in the DJ-1 gene have been described in autosomal recessive Parkinson's disease patients (ARPD) of European ancestry and young onset (YOPD) Ashkenazi Jewish and Afro-Caribbean patients. There is little information on the prevalence of DJ-1 mutations amongst Asian PD populations. In this study, we examined for DJ-1 mutations in consecutive YOPD and ARPD in a multi-ethnic cohort (Chinese, Malays, and Indians) of PD patients in a tertiary referral center. Sequence analysis of all the exons and the exon and intron boundaries of the DJ-1 gene were carried out. We did not find any DJ-1 mutations in these patients. A number of intronic variants with genotype frequency ranging from 15 to 90% were detected. Unlike Parkin, pathogenic DJ-1 mutations appear to be restricted to certain populations and are unlikely to be of clinical importance in our Asian cohort. 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
ISSN: 03043940
DOI: 10.1016/j.neulet.2004.05.090
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