Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2004.05.090
Title: Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity
Authors: Tan E.-K. 
Tan C.
Zhao Y.
Yew K.
Shen H.
Chandran V.R.
Teoh M.-L.
Yih Y.
Pavanni R. 
Wong M.-C. 
Keywords: DJ-1
Mutation
Parkinson's disease
Issue Date: 2004
Publisher: Elsevier
Citation: Tan E.-K., Tan C., Zhao Y., Yew K., Shen H., Chandran V.R., Teoh M.-L., Yih Y., Pavanni R., Wong M.-C. (2004). Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity. Neuroscience Letters 367 (1) : 109-112. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2004.05.090
Abstract: Mutations in the DJ-1 gene have been described in autosomal recessive Parkinson's disease patients (ARPD) of European ancestry and young onset (YOPD) Ashkenazi Jewish and Afro-Caribbean patients. There is little information on the prevalence of DJ-1 mutations amongst Asian PD populations. In this study, we examined for DJ-1 mutations in consecutive YOPD and ARPD in a multi-ethnic cohort (Chinese, Malays, and Indians) of PD patients in a tertiary referral center. Sequence analysis of all the exons and the exon and intron boundaries of the DJ-1 gene were carried out. We did not find any DJ-1 mutations in these patients. A number of intronic variants with genotype frequency ranging from 15 to 90% were detected. Unlike Parkin, pathogenic DJ-1 mutations appear to be restricted to certain populations and are unlikely to be of clinical importance in our Asian cohort. 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/150236
ISSN: 03043940
DOI: 10.1016/j.neulet.2004.05.090
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

31
checked on Sep 12, 2019

WEB OF SCIENCETM
Citations

22
checked on Dec 31, 2018

Page view(s)

29
checked on Sep 5, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.