Please use this identifier to cite or link to this item: https://doi.org/10.1002/mds.20504
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dc.titleAlpha-synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients
dc.contributor.authorBerg D.
dc.contributor.authorNiwar M.
dc.contributor.authorMaass S.
dc.contributor.authorZimprich A.
dc.contributor.authorMöller J.C.
dc.contributor.authorWuellner U.
dc.contributor.authorSchmitz-Hübsch T.
dc.contributor.authorKlein C.
dc.contributor.authorTan E.-K.
dc.contributor.authorSchöls L.
dc.contributor.authorMarsh L.
dc.contributor.authorDawson T.M.
dc.contributor.authorJanetzky B.
dc.contributor.authorMüller T.
dc.contributor.authorWoitalla D.
dc.contributor.authorKostic V.
dc.contributor.authorPramstaller P.P.
dc.contributor.authorOertel W.H.
dc.contributor.authorBauer P.
dc.contributor.authorKrueger R.
dc.contributor.authorGasser T.
dc.contributor.authorRiess O.
dc.date.accessioned2018-12-27T06:32:44Z
dc.date.available2018-12-27T06:32:44Z
dc.date.issued2005
dc.identifier.citationBerg D., Niwar M., Maass S., Zimprich A., Möller J.C., Wuellner U., Schmitz-Hübsch T., Klein C., Tan E.-K., Schöls L., Marsh L., Dawson T.M., Janetzky B., Müller T., Woitalla D., Kostic V., Pramstaller P.P., Oertel W.H., Bauer P., Krueger R., Gasser T., Riess O. (2005). Alpha-synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients. Movement Disorders 20 (9) : 1191-1194. ScholarBank@NUS Repository. https://doi.org/10.1002/mds.20504
dc.identifier.issn08853185
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/150232
dc.description.abstractData on the frequency of ?-synuclein mutations in Parkinson's disease (PD) are limited. Screening the entire coding region in 1,921 PD patients with denaturing high performance liquid chromatography and subsequent sequencing we only detected silent mutations (g.2654A>G, g.10151G>A, and g.15986A>T) and the c.209G>A substitution corresponding to the p.A53T mutation. These results demonstrate that mutations in the ?-synuclein gene are rare and suggest that other factors contribute to ?-synuclein aggregation in the majority of PD patients. 2005 Movement Disorder Society.
dc.publisherWiley
dc.sourceScopus
dc.subjectAlpha-synuclein
dc.subjectMutational screening
dc.subjectParkinson's disease
dc.subjectSilent mutation
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1002/mds.20504
dc.description.sourcetitleMovement Disorders
dc.description.volume20
dc.description.issue9
dc.description.page1191-1194
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