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Title: Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
Authors: Wang L.
Heckman M.G.
Aasly J.O.
Annesi G.
Bozi M.
Chung S.J.
Clarke C.
Crosiers D.
Eckstein G.
Garraux G.
Hadjigeorgiou G.M.
Hattori N.
Jeon B.
Kim Y.J.
Kubo M.
Lesage S.
Lin J.J.
Lynch T.
Lichtner P.
Mellick G.D.
Mok V.
Morrison K.E.
Quattrone A.
Satake W.
Silburn P.A.
Stefanis L.
Stockton J.D.
Tan E.K. 
Toda T.
Brice A.
Van Broeckhoven C.
Uitti R.J.
Wirdefeldt K.
Wszolek Z.
Xiromerisiou G.
Maraganore D.M.
Gasser T.
Krüger R.
Farrer M.J.
Ross O.A.
Sharma M.
Keywords: Genetic epidemiology
Parkinson's disease
Issue Date: 2017
Publisher: Elsevier
Citation: Wang L., Heckman M.G., Aasly J.O., Annesi G., Bozi M., Chung S.J., Clarke C., Crosiers D., Eckstein G., Garraux G., Hadjigeorgiou G.M., Hattori N., Jeon B., Kim Y.J., Kubo M., Lesage S., Lin J.J., Lynch T., Lichtner P., Mellick G.D., Mok V., Morrison K.E., Quattrone A., Satake W., Silburn P.A., Stefanis L., Stockton J.D., Tan E.K., Toda T., Brice A., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Maraganore D.M., Gasser T., Krüger R., Farrer M.J., Ross O.A., Sharma M. (2017). Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging 49 : 217.e1-217.e4. ScholarBank@NUS Repository.
Abstract: A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted. © 2016 Elsevier Inc.
Source Title: Neurobiology of Aging
ISSN: 1974580
DOI: 10.1016/j.neurobiolaging.2016.09.022
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