Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2016.09.022
Title: Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
Authors: Wang L.
Heckman M.G.
Aasly J.O.
Annesi G.
Bozi M.
Chung S.J.
Clarke C.
Crosiers D.
Eckstein G.
Garraux G.
Hadjigeorgiou G.M.
Hattori N.
Jeon B.
Kim Y.J.
Kubo M.
Lesage S.
Lin J.J.
Lynch T.
Lichtner P.
Mellick G.D.
Mok V.
Morrison K.E.
Quattrone A.
Satake W.
Silburn P.A.
Stefanis L.
Stockton J.D.
Tan E.K. 
Toda T.
Brice A.
Van Broeckhoven C.
Uitti R.J.
Wirdefeldt K.
Wszolek Z.
Xiromerisiou G.
Maraganore D.M.
Gasser T.
Krüger R.
Farrer M.J.
Ross O.A.
Sharma M.
Keywords: Genetic epidemiology
LRRK2
PARK16
Parkinson's disease
Issue Date: 2017
Publisher: Elsevier
Citation: Wang L., Heckman M.G., Aasly J.O., Annesi G., Bozi M., Chung S.J., Clarke C., Crosiers D., Eckstein G., Garraux G., Hadjigeorgiou G.M., Hattori N., Jeon B., Kim Y.J., Kubo M., Lesage S., Lin J.J., Lynch T., Lichtner P., Mellick G.D., Mok V., Morrison K.E., Quattrone A., Satake W., Silburn P.A., Stefanis L., Stockton J.D., Tan E.K., Toda T., Brice A., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Maraganore D.M., Gasser T., Krüger R., Farrer M.J., Ross O.A., Sharma M. (2017). Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging 49 : 217.e1-217.e4. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2016.09.022
Abstract: A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted. © 2016 Elsevier Inc.
Source Title: Neurobiology of Aging
URI: http://scholarbank.nus.edu.sg/handle/10635/150221
ISSN: 1974580
DOI: 10.1016/j.neurobiolaging.2016.09.022
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
j.neurobiolaging.2016.09.022.pdf46.36 kBAdobe PDF

OPEN

Pre-printView/Download

SCOPUSTM   
Citations

1
checked on Sep 21, 2020

Page view(s)

136
checked on Sep 18, 2020

Download(s)

2
checked on Sep 18, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.