Please use this identifier to cite or link to this item: https://doi.org/10.1002/sctm.16-0470
Title: Immature Midbrain Dopaminergic Neurons Derived from Floor-Plate Method Improve Cell Transplantation Therapy Efficacy for Parkinson's Disease
Authors: Qiu L. 
Liao M.-C.
Chen A.K.
Wei S.
Xie S. 
Reuveny S.
Zhou Z.D. 
Hunziker W. 
Tan E.K. 
Oh S.K.W. 
Zeng L. 
Keywords: Differentiation
Floor-plate
Midbrain dopaminergic neurons
Parkinson's disease
Transplantation
Tyrosine hydroxylase
Issue Date: 2017
Publisher: Wiley Open Access
Citation: Qiu L., Liao M.-C., Chen A.K., Wei S., Xie S., Reuveny S., Zhou Z.D., Hunziker W., Tan E.K., Oh S.K.W., Zeng L. (2017). Immature Midbrain Dopaminergic Neurons Derived from Floor-Plate Method Improve Cell Transplantation Therapy Efficacy for Parkinson's Disease. Stem Cells Translational Medicine 6 (9) : 1803-1814. ScholarBank@NUS Repository. https://doi.org/10.1002/sctm.16-0470
Abstract: Recent reports have indicated human embryonic stem cells-derived midbrain dopamine (mDA) neurons as proper cell resources for use in Parkinson's disease (PD) therapy. Nevertheless, no detailed and systematic study has been conducted to identify which differentiation stages of mDA cells are most suitable for transplantation in PD therapy. Here, we transplanted three types of mDA cells, DA progenitors (differentiated in vitro for 16 days [D16]), immature DA neurons (D25), and DA neurons (D35), into PD mice and found that all three types of cells showed high viability and strong neuronal differentiation in vivo. Both D25 and D35 cells showed neuronal maturation and differentiation toward TH+ cells and, accordingly, satisfactory behavioral functional recovery. However, transplanted D16 cells were less capable of producing functional recovery. These findings provide a valuable guideline for standardizing the differentiation stage of the transplantable cells used in clinical cell therapy for PD. Stem Cells Translational Medicine 2017;6:1803–1814. © 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press
Source Title: Stem Cells Translational Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/150219
ISSN: 21576564
DOI: 10.1002/sctm.16-0470
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