Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2018.04.003
Title: Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement
Authors: Ng A.S.L.
Tan Y.J. 
Yi Z.
Tandiono M.
Chew E.
Dominguez J.
Macas M.
Ng E.
Hameed S. 
Ting S. 
Tan E.K. 
Foo J.N.
Kandiah N. 
Keywords: Exome sequencing
Frontotemporal dementia
Genetics
TREM2
Issue Date: 2018
Publisher: Elsevier Inc.
Citation: Ng A.S.L., Tan Y.J., Yi Z., Tandiono M., Chew E., Dominguez J., Macas M., Ng E., Hameed S., Ting S., Tan E.K., Foo J.N., Kandiah N. (2018). Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement. Neurobiology of Aging 68 : 160.e15-160.e19. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2018.04.003
Abstract: To identify genes associated with frontotemporal dementia (FTD) in South-East Asia, targeted exome sequencing and C9orf72 genotyping was performed in 198 subjects (52 patients with FTD and 146 healthy controls) who were screened for mutations in 12 FTD-associated genes. We detected a homozygous TREM2 R47C mutation in a patient with behavioral variant FTD without bone cysts or bone-associated phenotype. Two novel nonsense GRN mutations in 3 FTD patients from the Philippines were detected, but no known pathogenic mutations in other FTD-associated genes were found. In 45 subjects screened for C9orf72 repeat expansions, no pathogenic expansion (?30 repeats) was identified, but there was a higher proportion of intermediate length (?10�29 repeats) alleles in patients compared with controls (8/90 alleles, 8.9% vs. 9/164 alleles, 5.5%). Overall, we detected a mutation rate of 7.7% (4/52 patients) in our cohort. Given recent findings of enrichment of rare TREM2 variants (including R47C) in Alzheimer's disease, it is notable that we detected a homozygous TREM2 R47C carrier presenting with an FTD rather than an Alzheimer's disease phenotype. � 2018 Elsevier Inc.
Source Title: Neurobiology of Aging
URI: http://scholarbank.nus.edu.sg/handle/10635/150208
ISSN: 1974580
DOI: 10.1016/j.neurobiolaging.2018.04.003
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