Please use this identifier to cite or link to this item: https://doi.org/10.1002/mds.25841
Title: Alpha-synuclein repeat variants and survival in parkinson's disease
Authors: Chung S.J.
Biernacka J.M.
Armasu S.M.
Anderson K.
Frigerio R.
Aasly J.O.
Annesi G.
Bentivoglio A.R.
Brighina L.
Chartier-Harlin M.-C.
Goldwurm S.
Hadjigeorgiou G.
Jasinska-Myga B.
Jeon B.S.
Kim Y.J.
Krüger R.
Lesage S.
Markopoulou K.
Mellick G.
Morrison K.E.
Puschmann A.
Tan E.-K. 
Crosiers D.
Theuns J.
Van Broeckhoven C.
Wirdefeldt K.
Wszolek Z.K.
Elbaz A.
Maraganore D.M.
Yahalom G.
Orlev Y.
Cohen O.S.
Kozlova E.
Friedman E.
Inzelberg R.
Hassin-Baer S.
Issue Date: 2014
Publisher: John Wiley and Sons Inc.
Citation: Chung S.J., Biernacka J.M., Armasu S.M., Anderson K., Frigerio R., Aasly J.O., Annesi G., Bentivoglio A.R., Brighina L., Chartier-Harlin M.-C., Goldwurm S., Hadjigeorgiou G., Jasinska-Myga B., Jeon B.S., Kim Y.J., Krüger R., Lesage S., Markopoulou K., Mellick G., Morrison K.E., Puschmann A., Tan E.-K., Crosiers D., Theuns J., Van Broeckhoven C., Wirdefeldt K., Wszolek Z.K., Elbaz A., Maraganore D.M., Yahalom G., Orlev Y., Cohen O.S., Kozlova E., Friedman E., Inzelberg R., Hassin-Baer S. (2014). Alpha-synuclein repeat variants and survival in parkinson's disease. Movement Disorders 29 (8) : 1053-1057. ScholarBank@NUS Repository. https://doi.org/10.1002/mds.25841
Abstract: Objectives: To determine whether ?-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between ?-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, ?-synuclein REP1 genotypes were not associated with survival in PD. Further studies of ?-synuclein's role in disease progression and long-term outcomes are needed. © 2014 International Parkinson and Movement Disorder Society.
Source Title: Movement Disorders
URI: http://scholarbank.nus.edu.sg/handle/10635/150111
ISSN: 8853185
DOI: 10.1002/mds.25841
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