Please use this identifier to cite or link to this item:
Title: Alpha-synuclein repeat variants and survival in parkinson's disease
Authors: Chung S.J.
Biernacka J.M.
Armasu S.M.
Anderson K.
Frigerio R.
Aasly J.O.
Annesi G.
Bentivoglio A.R.
Brighina L.
Chartier-Harlin M.-C.
Goldwurm S.
Hadjigeorgiou G.
Jasinska-Myga B.
Jeon B.S.
Kim Y.J.
Krüger R.
Lesage S.
Markopoulou K.
Mellick G.
Morrison K.E.
Puschmann A.
Tan E.-K. 
Crosiers D.
Theuns J.
Van Broeckhoven C.
Wirdefeldt K.
Wszolek Z.K.
Elbaz A.
Maraganore D.M.
Yahalom G.
Orlev Y.
Cohen O.S.
Kozlova E.
Friedman E.
Inzelberg R.
Hassin-Baer S.
Issue Date: 2014
Publisher: John Wiley and Sons Inc.
Citation: Chung S.J., Biernacka J.M., Armasu S.M., Anderson K., Frigerio R., Aasly J.O., Annesi G., Bentivoglio A.R., Brighina L., Chartier-Harlin M.-C., Goldwurm S., Hadjigeorgiou G., Jasinska-Myga B., Jeon B.S., Kim Y.J., Krüger R., Lesage S., Markopoulou K., Mellick G., Morrison K.E., Puschmann A., Tan E.-K., Crosiers D., Theuns J., Van Broeckhoven C., Wirdefeldt K., Wszolek Z.K., Elbaz A., Maraganore D.M., Yahalom G., Orlev Y., Cohen O.S., Kozlova E., Friedman E., Inzelberg R., Hassin-Baer S. (2014). Alpha-synuclein repeat variants and survival in parkinson's disease. Movement Disorders 29 (8) : 1053-1057. ScholarBank@NUS Repository.
Abstract: Objectives: To determine whether ?-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between ?-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, ?-synuclein REP1 genotypes were not associated with survival in PD. Further studies of ?-synuclein's role in disease progression and long-term outcomes are needed. © 2014 International Parkinson and Movement Disorder Society.
Source Title: Movement Disorders
ISSN: 8853185
DOI: 10.1002/mds.25841
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
mds.25841.pdf268.66 kBAdobe PDF




checked on Jul 11, 2020


checked on Dec 24, 2018

Page view(s)

checked on Jul 10, 2020


checked on Jul 10, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.