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Title: Role of c-Jun in the regulation of tumor suppressor p53 homologue, p73
Keywords: Jun; TA-p73; ΔN-p73 ; Cisplatin; UV
Issue Date: 2-Dec-2005
Citation: LAKSHMANANE BOOMINATHAN (2005-12-02). Role of c-Jun in the regulation of tumor suppressor p53 homologue, p73. ScholarBank@NUS Repository.
Abstract: This study proposes for the first time that the transcription factor c-Jun stabilizes and activates p73. Genetic evidences consolidated the findings, as c-jun-/- cells are defective in p73 stabilization, transcriptional activation, and are resistant to cisplatin induced apoptosis. Upon introducing c-Jun in c-jun-/- cells restores p73 stabilization, activation, and sensitivity to cisplatin. UV radiation increases p73 levels in a variety of cell lines analyzed. In a parallel study, p73 increases AP-1 activity and it synergies with c-Jun to increase the expression of AP-1 dependent target genes. The NH2-terminus of p73 is necessary to synergizes with c-Jun. JNK-mediated c-Jun phosphorylation is required for its ability to co-operate with p73. Basal level of AP-1 activity was lowered by the dominant negative p73. Further, this study suggests the existence of a regulatory loop between the TA-p73/I?N-p73 and c-Jun. Collectively, this study indicates that c-Jun and p73 regulate each other in cell fate decisions.
Appears in Collections:Ph.D Theses (Open)

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