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|Title:||Reperfusion hemorrhage following acute myocardial infarction: Assessment with T2*mapping and effect on measuring the area at risk||Authors:||O'Regan D.P.
|Issue Date:||2009||Publisher:||Radiological Society of North America||Citation:||O'Regan D.P., Ahmed R., Karunanithy N., Neuwirth C., Tan Y., Durighel G., Hajnal J.V., Nadra I., Corbett S.J., Cook S.A. (2009). Reperfusion hemorrhage following acute myocardial infarction: Assessment with T2*mapping and effect on measuring the area at risk. Radiology 250 (3) : 916-922. ScholarBank@NUS Repository. https://doi.org/10.1148/radiol.2503081154||Abstract:||Research ethics committee approval and informed consent were obtained. The purpose of this study was to assess the feasibility of multiecho T2*mapping of the heart for detecting reperfusion hemorrhage following percutaneous primary coronary intervention (PPCI) for acute myocar-dial infarction, and to measure the effect of hemorrhage on quantifying the ischemic area at risk (IAR) on T2-weighted magnetic resonance images. Fifteen patients (mean age, 59 years;13 men, two women) were imaged a mean of 3.2 days following PPCI. The mean area of hemorrhage, indicated by a T2*decay constant of less than 20 msec, was 5.0% �4.9 (standard deviation) at the level of the infarct and this correlated with the infarct (r2 = 0.76, P <.01) and microvascular obstruction (r2 = 0.75, P <.01) volumes. When 5% or less hemorrhage was present, the IAR was underestimated by 50% at a standard deviation threshold level of five, compared with a boundary detection tool (21.8% vs 44.0%, P <.05). T2*mapping is feasible for quantifying post-reperfusion hemorrhage and boundary detection is required to accurately assess the IAR when hemorrhage is present. � RSNA, 2009.||Source Title:||Radiology||URI:||http://scholarbank.nus.edu.sg/handle/10635/149993||ISSN:||00338419||DOI:||10.1148/radiol.2503081154|
|Appears in Collections:||Staff Publications|
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