Please use this identifier to cite or link to this item:
Title: Study of drug release behaviour from HPMC matrix tablets and EC coated matrix reservoir system
Keywords: matrix tablets, HPMC, EC coating, reservoir system, particle size, coating level
Issue Date: 31-Oct-2005
Citation: LI XIAOMAN (2005-10-31). Study of drug release behaviour from HPMC matrix tablets and EC coated matrix reservoir system. ScholarBank@NUS Repository.
Abstract: In monolithic matrix systems, particle size properties of the controlled release polymer, HPMC, had significant impact on drug release performance. The rate of drug released from the matrix tablet generally decreased as the mean particle size of HPMC was reduced. The drug release mechanism was affected by HPMC mean particle size and concentration. Drug release constant was proportionally related to polymer mean particle size and relative number of polymer particles in the matrix system.The release performance of naproxen sodium and aspirin from EC coated HPMC matrices was studied. The release of aspirin was more sensitive to EC coating level, while that of naproxen sodium was influenced more significantly by HPMC content in the core. Application of EC coating suppressed drug release rate and the magnitude of suppression was dependent on the coating thickness and soluble additive concentration.
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Li Xiaoman.pdf965.25 kBAdobe PDF



Page view(s)

checked on Apr 20, 2019


checked on Apr 20, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.