Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/149545
Title: IDENTIFICATION OF POST-TRANSCRIPTIONAL REGULATORS OF MYC IN COLORECTAL CANCER
Authors: DESI
ORCID iD:   orcid.org/0000-0001-8167-3925
Keywords: MYC, Post-transcriptional, LARP1, MicroRNA, MiR-138-5p, Colorectal Cancer
Issue Date: 20-Aug-2018
Citation: DESI (2018-08-20). IDENTIFICATION OF POST-TRANSCRIPTIONAL REGULATORS OF MYC IN COLORECTAL CANCER. ScholarBank@NUS Repository.
Abstract: Elevated MYC transcript levels in colorectal cancer (CRC) patients highlight the importance of MYC regulation in CRC development. In my thesis, I explored alternative strategies that could modulate MYC expression and identified two post-transcriptional regulators. Firstly, I identified LARP1 as an RBP which associates with the MYC 3′UTR, thereby positively regulating MYC expression. In addition, I discovered that MYC is a positive regulator of LARP1 at the transcriptional level. Secondly, I identified miR-138-5p as a negative regulator of MYC expression via its targeting of the MYC coding sequence (CDS). Overexpression of miR-138-5p decreases MYC expression and inhibits CRC tumorigenesis in vitro, while the inhibition of miR-138-5p reverses these effects. The elucidation of the mechanistic roles of these two post-transcriptional regulators of MYC provides a better understanding of the molecular basis of MYC dysregulation in CRC and may serve as alternatives for treatment of MYC-driven CRC and possibly other MYC-driven cancers.
URI: http://scholarbank.nus.edu.sg/handle/10635/149545
Appears in Collections:Ph.D Theses (Open)

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