Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/149306
Title: PERSONALISED DRUG DELIVERY AND TESTING BY 3D PRINTING
Authors: LIM SENG HAN
Keywords: 3D printing, microneedle, personalised medicine, transdermal, drug testing
Issue Date: 17-Aug-2018
Citation: LIM SENG HAN (2018-08-17). PERSONALISED DRUG DELIVERY AND TESTING BY 3D PRINTING. ScholarBank@NUS Repository.
Abstract: Individualization emerges as a major challenge in clinical practices. However, current manufacturing of personalised drug dosage forms and testing devices is not efficient. Utilising a low-cost 3D printer (Fused Deposition Modelling), a customisable, zero-order release kinetic oral tablet scaffold was developed. However, peptide drugs that hold huge potential, may not be suitable for oral administration. Subsequently, a high-resolution 3D printer (Digital Light Processing) was employed to fabricate personalised microneedle patch for the transdermal delivery of peptide. Microneedle geometry and 3D printable, photocurable materials were optimised. Beyond a drug delivery device, a dual function microneedle splint was also developed to deliver NSAIDs and to immobilise the affected finger joint for patients with trigger finger. Finally, a proof of concept for a personalised human respiratory tract model assembly was developed for inhalation drug testing. Overall, this thesis demonstrated the suitability of 3D printing for fabrication of personalised drug delivery and testing systems.
URI: http://scholarbank.nus.edu.sg/handle/10635/149306
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
LimSH.pdf2.25 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

61
checked on Jan 15, 2021

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.