Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.yjmcc.2008.11.005
DC FieldValue
dc.titleAre transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?
dc.contributor.authorCook S.A.
dc.contributor.authorClerk A.
dc.contributor.authorSugden P.H.
dc.date.accessioned2018-11-29T07:17:28Z
dc.date.available2018-11-29T07:17:28Z
dc.date.issued2009
dc.identifier.citationCook S.A., Clerk A., Sugden P.H. (2009). Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?. Journal of Molecular and Cellular Cardiology 46 (2) : 118-129. ScholarBank@NUS Repository. https://doi.org/10.1016/j.yjmcc.2008.11.005
dc.identifier.issn222828
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/149279
dc.description.abstractMurine transgenesis using cardioselective promoters has become increasingly common in studies of cardiac hypertrophy and heart failure, with expression mediated by pronuclear microinjection being the commonest format. Without wishing to decry their usefulness, in our view, such studies are not necessarily as unambiguous as sometimes portrayed and clarity is not always their consequence. We describe broadly the types of approach undertaken in the heart and point out some of the drawbacks. We provide three arbitrarily-chosen examples where, in spite of a number of often-independent studies, no consensus has yet been achieved. These include glycogen synthase kinase 3, the extracellular signal-regulated kinase pathway and the ryanodine receptor 2. We believe that the transgenic approach should not be viewed in an empyreal light and, depending on the questions asked, we suggest that other experimental systems provide equal (or even more) valuable outcomes. � 2008 Elsevier Inc. All rights reserved.
dc.publisherScienceDirect
dc.sourceScopus
dc.subject?-myosin heavy chain promoter
dc.subjectCardioselectivity
dc.subjectEnd-points
dc.subjectExtracellular signal-regulated kinase 1/2 cascade
dc.subjectGenetic background and strain effects
dc.subjectGlycogen synthase kinase 3
dc.subjectIntracellular localisation
dc.subjectPoison proteins
dc.subjectProtein kinase B/Akt
dc.subjectRyanodine receptor 2
dc.subjectSignal strength matching
dc.subjectTrangenesis
dc.typeReview
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.yjmcc.2008.11.005
dc.description.sourcetitleJournal of Molecular and Cellular Cardiology
dc.description.volume46
dc.description.issue2
dc.description.page118-129
dc.published.statepublished
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