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Title: Roles of CASPA2 and HGC1 in morphological control and virulence in candida albicans
Keywords: C. albicans, morphology, polarity, virulence, cyclin, cell cycle
Issue Date: 21-Oct-2005
Citation: ZHENG XINDE (2005-10-21). Roles of CASPA2 and HGC1 in morphological control and virulence in candida albicans. ScholarBank@NUS Repository.
Abstract: Candida albicans is one of the most important human fungal pathogens. It is a polymorphic fungus and can switch from oval shaped yeast form to a highly elongated, branching hyphal form in response to a variety of environmental stimuli. The morphology switching ability of C. albicans has been proposed to be a key virulence trait. In this thesis, the role of two genes, CaSPA2 and HGC1, in the morphological control is described. CaSpa2, a component of polarisome, plays important role in polarity establishment and maintenance in both yeast and hyphal growth form. A novel gene HGC1, encoding a G1 cyclin-like protein was identified and found to have a specific role in regulating hyphal growth. HGC1 transcript can only be detected in hyphal cells, and deletion analyses proved that HGC1 is essential for hyphal development. In mouse systemic infection model, the virulence of the respective deletion mutant of HGC1 and CaSPA2 was dramatically decreased, indicating that these two genes are important for the full virulence of C. albicans.
Appears in Collections:Ph.D Theses (Open)

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