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|Title:||Palindrome distributions and their applications||Authors:||QIN XUAN||Keywords:||DNA sequences, palindrome distributions, Markov chain, under- and||Issue Date:||20-Oct-2005||Citation:||QIN XUAN (2005-10-20). Palindrome distributions and their applications. ScholarBank@NUS Repository.||Abstract:||We analyze DNA palindromes in the Coronavirus and Herpesvirus families. Specifically we study two problems. Problem 1 deals with the overall count of palindromes of a certain length in a genome where we compare the observed number of palindromes of a certain length against its expected number under Markov chain sequence models of the genome. We derive expressions for the mean and standard deviation of the number of palindromes. The resulting z-score enables us to explore whether the observed number of palindromes of a certain length is over- (or under-)represented.Problem 2 deals with a measure of local clusters of nearly palindromes at or above a certain length. This measure leads to a statistical procedure to predict the replication origins of these viruses.||URI:||http://scholarbank.nus.edu.sg/handle/10635/14918|
|Appears in Collections:||Master's Theses (Open)|
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