Please use this identifier to cite or link to this item: https://doi.org/10.1097/FPC.0b013e328306c2f2
Title: The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinsons disease, levodopa treatment response, and complications
Authors: Bialecka M.
Kurzawski M.
Klodowska-Duda G.
Opala G.
Tan E.-K. 
Drozdzik M.
Keywords: Catechol-O-methyltransferase
Genetic polymorphism
Haplotypes
Parkinsons disease
Single nucleotide polymorphisms
Issue Date: 2008
Publisher: Lippincott, Williams & Wilkins
Citation: Bialecka M., Kurzawski M., Klodowska-Duda G., Opala G., Tan E.-K., Drozdzik M. (2008). The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinsons disease, levodopa treatment response, and complications. Pharmacogenetics and Genomics 18 (9) : 815-821. ScholarBank@NUS Repository. https://doi.org/10.1097/FPC.0b013e328306c2f2
Abstract: INTRODUCTION: Differences in catechol-O-methyltransferase (COMT) activity and genotype may determine individual variations in the therapeutic response to levodopa or Parkinsons disease (PD) susceptibility. The role of functional COMT haplotypes in PD susceptibility and treatment response has not been examined. OBJECTIVES: In this case "control study, we investigated the association of the most common COMT gene haplotypes (formed by single nucleotide polymorphisms (SNPs): rs6269:A>G; rs4633C>T; rs4818:C>G; and rs4680:A>G) with PD risk and the association of the COMT haplotypes with the dose and complications of levodopa therapy in PD patients. METHODS: A total of 679 study participants (322 PD and 357 controls) were included. Each participant was genotyped for four SNPs in the COMT gene, located in a common haploblock, that has been shown to influence COMT enzymatic activity. The influence of COMT haplotypes on the dose of levodopa administered during fifth year of treatment, and occurrence of motor complications were examined in PD patients. The EH program (Jurg Ott, Rockefeller University, New York, USA) was used to estimate haplotype frequencies. RESULTS: The estimated frequencies of low (A-C-C-G) and medium (A-T-C-A) activity haplotypes tended to be slightly lower among PD patients when compared with controls (P?0.09, G-C-G-G-high activity haplotype as reference). The frequency of G-C-G-G (high activity) haplotype carriers was higher in late onset PD patients (P?0.04) compared with controls. The mean levodopa dose increased with the activity of the functional haplotypes (low
Source Title: Pharmacogenetics and Genomics
URI: http://scholarbank.nus.edu.sg/handle/10635/149152
ISSN: 17446872
DOI: 10.1097/FPC.0b013e328306c2f2
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

57
checked on Apr 17, 2019

WEB OF SCIENCETM
Citations

53
checked on Dec 31, 2018

Page view(s)

5
checked on Jan 10, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.