Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep15492
Title: Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson's Disease
Authors: Kumar P.M. 
Paing S.S.T.
Li H.
Pavanni R.
Yuen Y.
Zhao Y.
Tan E.K. 
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Kumar P.M., Paing S.S.T., Li H., Pavanni R., Yuen Y., Zhao Y., Tan E.K. (2015). Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson's Disease. Scientific Reports 5 : 15492. ScholarBank@NUS Repository. https://doi.org/10.1038/srep15492
Abstract: We examined if caffeine intake has a differential effect in subjects with high and low genetic susceptibility to Parkinson's disease (PD), a common neurodegenerative disorder. A case control study involving 812 subjects consisting of PD and healthy controls were conducted. Caffeine intake assessed by a validated questionnaire and genotyping of PD gene risk variant (LRRK2 R1628P) was carried out. Compared to caffeine takers with the wild-type genotype (low genetic susceptibility), non-caffeine takers with R1628P variant (high genetic susceptibility) had a 15 times increased risk of developing PD (OR = 15.4, 95% CI = (1.94, 122), P = 0.01), whereas caffeine takers with R1628P (intermediate susceptibility) had a 3 times risk (OR = 3.07, 95% CI = (2.02, 4.66), P < 0.001). Caffeine intake would significantly reduce the risk of PD much more in those with high genetic susceptibility compared to those with low genetic susceptibility.
Source Title: Scientific Reports
URI: http://scholarbank.nus.edu.sg/handle/10635/149126
ISSN: 2045-2322
DOI: 10.1038/srep15492
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