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Title: Deterministic Tractography of the Nigrostriatal-Nigropallidal Pathway in Parkinson's Disease
Authors: Tan W.-Q.
Yeoh C.-S.
Rumpel H.
Nadkarni N. 
Lye W.-K. 
Tan E.-K. 
Chan L.-L. 
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Tan W.-Q., Yeoh C.-S., Rumpel H., Nadkarni N., Lye W.-K., Tan E.-K., Chan L.-L. (2015). Deterministic Tractography of the Nigrostriatal-Nigropallidal Pathway in Parkinson's Disease. Scientific Reports 5 : 17283. ScholarBank@NUS Repository.
Abstract: We hypothesized that deterministic tractography is practical and sensitive to changes in the complex nigrostriatal and nigropallidal pathway (NSP) in Parkinsonâ ™ s disease (PD). Using diffusion tensor imaging (DTI) tractography, we investigated the NSP to evaluate differences between PD patients and controls, and examined their clinico-radiologic correlation. Structural and DTI brain scans were obtained in 40 subjects (21 PD patients and 19 healthy controls). We isolated the NSP using a user-friendly DTI toolkit based on deterministic brute-force tractography. DTI parameters of fractional anisotropy (FA), mean, axial, and radial diffusivity, and streamline count of the NSP were measured. Average FA (p < 0.01) and streamline count (p < 0.001) were significantly lower in the PD compared to control group. Mean diffusivity and radial diffusivity were significantly higher in the PD group (p < 0.05). Average streamline count correlated with the United Parkinsonâ ™ s Disease Rating Scale motor score (p < 0.05). Point-to-point FA profiles of the tract demonstrated peak divergence between PD and control towards the tract midpoint rather than the distal grey matter. Our findings demonstrated a clinically and radiologically practical application of DTI tractography to the NSP in PD, without requiring complex imaging sequences for anatomical localization or segmentation software.
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/srep17283
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