Please use this identifier to cite or link to this item:
Title: Deciphering the function and regulation of microRNAs in Alzheimer's disease and Parkinson's disease
Authors: Qiu L.
Zhang W.
Tan E.K. 
Zeng L. 
Keywords: Alzheimer's disease
neuronal survival
Parkinson's disease
Issue Date: 2014
Publisher: American Chemical Society
Citation: Qiu L., Zhang W., Tan E.K., Zeng L. (2014). Deciphering the function and regulation of microRNAs in Alzheimer's disease and Parkinson's disease. ACS Chemical Neuroscience 5 (10) : 884-894. ScholarBank@NUS Repository.
Abstract: MicroRNAs (miRNAs) are single stranded, noncoding RNA molecules that are encoded by eukaryotic nuclear DNA. miRNAs function through imperfect base-pairing with complementary sequences of target mRNA molecules, which is typically via the cleavage of target mRNA with transcriptional repression or translational degradation. An increasing number of studies identified dysregulation of miRNAs in neurodegenerative disease and suggest that alterations in the miRNA regulatory pathway could contribute to the disease pathogenesis. However, molecular mechanisms underlying the pathological implications of dysregulated miRNA expression and regulation of the key genes that are involved in neurodegenerative diseases remain largely unknown. Here, we review the evidence for the functional role of dysregulated miRNAs involved in disease pathogenesis, as well as how miRNAs govern neuronal functions either upstream or downstream of target genes that are disease pathogenic factors. Furthermore, we review the cellular feedback regulation between miRNAs and target genes in neurodegenerative diseases, with a focus on Alzheimer's disease and Parkinson's disease. � 2014 American Chemical Society.
Source Title: ACS Chemical Neuroscience
ISSN: 1948-7193
DOI: 10.1021/cn500149w
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Aug 26, 2019


checked on Jul 17, 2019

Page view(s)

checked on Aug 15, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.