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https://doi.org/10.1007/s00415-015-7855-8
DC Field | Value | |
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dc.title | Sexual dysfunction is associated with postural instability gait difficulty subtype of Parkinson's disease | |
dc.contributor.author | Deng X. | |
dc.contributor.author | Xiao B. | |
dc.contributor.author | Li H.-H. | |
dc.contributor.author | Lo Y.-L. | |
dc.contributor.author | Chew L.-M. | |
dc.contributor.author | Prakash K.M. | |
dc.contributor.author | Tan E.-K. | |
dc.date.accessioned | 2018-11-27T07:22:28Z | |
dc.date.available | 2018-11-27T07:22:28Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Deng X., Xiao B., Li H.-H., Lo Y.-L., Chew L.-M., Prakash K.M., Tan E.-K. (2015). Sexual dysfunction is associated with postural instability gait difficulty subtype of Parkinson's disease. Journal of Neurology 262 (11) : 2433-2439. ScholarBank@NUS Repository. https://doi.org/10.1007/s00415-015-7855-8 | |
dc.identifier.issn | 0340-5354 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/149104 | |
dc.description.abstract | The pathophysiology of the postural instability gait difficulty (PIGD) subtype of Parkinson's disease (PD) is unclear. Information on the spectrum of non-motor symptoms (NMS) in PIGD phenotype is limited. Our objective is to compare the spectrum of NMS in PIGD subtype compared to non-PIGD subgroup in PD patients and to determine predictive factors that are associated with PIGD phenotype. A total of 432 PD patients comprising 158 PIGD and 274 non-PIGD patients were recruited. NMS burden (frequency and severity) was assessed using non-motor symptom scale (NMSS). In the univariable analysis, NMSS total score (P = 0.0132), NMSS domain 3 (mood/apathy) score (P = 0.0108), NMSS domain 5 (attention/memory) score (P = 0.0048) and NMSS domain 8 (sexual function) score (P�=�0.0052) were significantly higher in the PIGD group than in the non-PIGD group. Using multivariable logistic regression, UPDRS tremor score, UPDRS PIGD score, H&Y staging score and NMSS domain 8 (sexual function) score were found to be significantly different in the PIGD group compared to the non-PIGD group. We disclosed for the first time that PIGD patients demonstrated a greater overall NMS burden and sexual dysfunction and was an independent predictor of PIGD phenotype. Early intervention of sexual dysfunction symptoms in PIGD patients may improve their clinical management. @ 2015, Springer-Verlag Berlin Heidelberg. | |
dc.publisher | Dr. Dietrich Steinkopff Verlag GmbH and Co. KG | |
dc.subject | Non-motor symptoms | |
dc.subject | Parkinson's disease | |
dc.subject | Postural instability gait difficulty | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1007/s00415-015-7855-8 | |
dc.description.sourcetitle | Journal of Neurology | |
dc.description.volume | 262 | |
dc.description.issue | 11 | |
dc.description.page | 2433-2439 | |
dc.description.coden | JNRYA | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications |
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