Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00415-015-7855-8
Title: Sexual dysfunction is associated with postural instability gait difficulty subtype of Parkinson's disease
Authors: Deng X.
Xiao B.
Li H.-H.
Lo Y.-L. 
Chew L.-M.
Prakash K.M. 
Tan E.-K. 
Keywords: Non-motor symptoms
Parkinson's disease
Postural instability gait difficulty
Issue Date: 2015
Publisher: Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
Citation: Deng X., Xiao B., Li H.-H., Lo Y.-L., Chew L.-M., Prakash K.M., Tan E.-K. (2015). Sexual dysfunction is associated with postural instability gait difficulty subtype of Parkinson's disease. Journal of Neurology 262 (11) : 2433-2439. ScholarBank@NUS Repository. https://doi.org/10.1007/s00415-015-7855-8
Abstract: The pathophysiology of the postural instability gait difficulty (PIGD) subtype of Parkinson's disease (PD) is unclear. Information on the spectrum of non-motor symptoms (NMS) in PIGD phenotype is limited. Our objective is to compare the spectrum of NMS in PIGD subtype compared to non-PIGD subgroup in PD patients and to determine predictive factors that are associated with PIGD phenotype. A total of 432 PD patients comprising 158 PIGD and 274 non-PIGD patients were recruited. NMS burden (frequency and severity) was assessed using non-motor symptom scale (NMSS). In the univariable analysis, NMSS total score (P = 0.0132), NMSS domain 3 (mood/apathy) score (P = 0.0108), NMSS domain 5 (attention/memory) score (P = 0.0048) and NMSS domain 8 (sexual function) score (P�=�0.0052) were significantly higher in the PIGD group than in the non-PIGD group. Using multivariable logistic regression, UPDRS tremor score, UPDRS PIGD score, H&Y staging score and NMSS domain 8 (sexual function) score were found to be significantly different in the PIGD group compared to the non-PIGD group. We disclosed for the first time that PIGD patients demonstrated a greater overall NMS burden and sexual dysfunction and was an independent predictor of PIGD phenotype. Early intervention of sexual dysfunction symptoms in PIGD patients may improve their clinical management. @ 2015, Springer-Verlag Berlin Heidelberg.
Source Title: Journal of Neurology
URI: http://scholarbank.nus.edu.sg/handle/10635/149104
ISSN: 0340-5354
DOI: 10.1007/s00415-015-7855-8
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