Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.scr.2016.12.010
Title: Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson's disease linked LRRK2 variant S1647T
Authors: Ma D. 
Ng S.H.
Zeng L. 
Zhao Y.
Tan E.K. 
Issue Date: 2017
Publisher: Elsevier B.V.
Citation: Ma D., Ng S.H., Zeng L., Zhao Y., Tan E.K. (2017). Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson's disease linked LRRK2 variant S1647T. Stem Cell Research 18 : 54-56. ScholarBank@NUS Repository. https://doi.org/10.1016/j.scr.2016.12.010
Abstract: Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with S1647T variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus reprogramming system. The transgene-free iPSC showed pluripotency confirmed by immunofluorescent staining for pluripotency markers and differentiated into the 3 germ layers in vivo. The iPSC line also showed normal karyotype. This cellular model will be useful for further function studies and therapeutic screening. � 2016 The Authors
Source Title: Stem Cell Research
URI: http://scholarbank.nus.edu.sg/handle/10635/149000
ISSN: 18735061
DOI: 10.1016/j.scr.2016.12.010
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