Please use this identifier to cite or link to this item: https://doi.org/10.1111/ene.13785
Title: No association of DNM3 with age of onset in Asian Parkinson's disease
Authors: Foo J.N.
Tan L.C.
Au W.-L.
Prakash K.-M.
Liu J.
Tan E.-K. 
Keywords: age of onset
human genetics
modifiers
Parkinson's disease
Issue Date: 2018
Publisher: Blackwell Publishing Ltd
Citation: Foo J.N., Tan L.C., Au W.-L., Prakash K.-M., Liu J., Tan E.-K. (2018). No association of DNM3 with age of onset in Asian Parkinson's disease. European Journal of Neurology. ScholarBank@NUS Repository. https://doi.org/10.1111/ene.13785
Abstract: Background and purpose: Genetic variability in DNM3 has been shown to modify age of onset of Parkinson's disease (PD) among LRRK2 Gly2019Ser carriers in North African Arab�Berber populations. In Asian populations, the Gly2019Ser mutation is rare or absent but two other LRRK2 variants, Gly2385Arg and Arg1628PPro, increase PD risk. We aimed to determine whether the DNM3 locus was associated with age of PD onset in both carriers and non-carriers of LRRK2 risk variants in Asians. Methods: We analyzed the association of DNM3 rs2421947 genotypes with age of PD onset in 3645 Chinese samples, of which 369 carried at least one of two Asian LRRK2 risk variants. Results: DNM3 rs2421947 genotypes were not associated with age of PD onset in Chinese samples. We observed no heterogeneity in the effect of rs2421947 between the Asian LRRK2 risk variant carriers and non-carriers. Conclusions: DNM3 rs2421947 was not associated with age of PD onset in LRRK2 risk variant carriers and non-carriers in Chinese samples. Further studies in other Asian populations will be of interest. � 2018 EAN
Source Title: European Journal of Neurology
URI: http://scholarbank.nus.edu.sg/handle/10635/148983
ISSN: 13515101
DOI: 10.1111/ene.13785
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

1
checked on Aug 19, 2019

WEB OF SCIENCETM
Citations

1
checked on Jul 17, 2019

Page view(s)

18
checked on Aug 15, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.