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|Title:||A novel membrane pool of protein kinase C and its role in mammalian cell signaling||Authors:||ZHU YIMIN||Keywords:||serine/threonine kinase, protein kinase C alpha, protein kinase C-related kinase 1, integral membrane protein, cell signaling, phosphorylation||Issue Date:||18-Aug-2005||Citation:||ZHU YIMIN (2005-08-18). A novel membrane pool of protein kinase C and its role in mammalian cell signaling. ScholarBank@NUS Repository.||Abstract:||This thesis describes studies that identify a novel integral plasma membrane pool of protein kinase C superfamily of serine/threonine protein kinases. In addition to demonstrating that neither classic transmembrane domains nor lipid anchors is responsible for membrane integration, mechanisms underlying the integration of a small portion of total cellular pool of PKC isozymes into membranes in vivo are explored. The functional importance of the novel integral plasma membrane pool of PKCs has been demonstrated through a series of functional assays in a number of mammalian cell lines. The work provides fresh insights into the in vivo isozyme specificity as well as efficiency and accuracy of PKC signaling. As a result, a novel paradigm in protein kinase C signaling has been defined that will impact not only on fundamentals of mammalian cell signaling but also on the designing of new therapeutic strategies for treating diseases such as cancer, neurodegenerative disorders and autoimmune diseases.||URI:||http://scholarbank.nus.edu.sg/handle/10635/14894|
|Appears in Collections:||Ph.D Theses (Open)|
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