Please use this identifier to cite or link to this item: https://doi.org/10.1186/1532-429X-14-41
Title: Remodeling after acute myocardial infarction: Mapping ventricular dilatation using three dimensional CMR image registration
Authors: Oregan D.P.
Shi W.
Ariff B.
Baksi A.J.
Durighel G.
Rueckert D.
Cook S.A. 
Keywords: Acute myocardial infarction
Cardiovascular magnetic resonance
Image analysis
Issue Date: 2012
Publisher: BioMed Central Ltd.
Citation: Oregan D.P., Shi W., Ariff B., Baksi A.J., Durighel G., Rueckert D., Cook S.A. (2012). Remodeling after acute myocardial infarction: Mapping ventricular dilatation using three dimensional CMR image registration. Journal of Cardiovascular Magnetic Resonance 14 (1) : 41. ScholarBank@NUS Repository. https://doi.org/10.1186/1532-429X-14-41
Abstract: Background: Progressive heart failure due to remodeling is a major cause of morbidity and mortality following myocardial infarction. Conventional clinical imaging measures global volume changes, and currently there is no means of assessing regional myocardial dilatation in relation to ischemic burden. Here we use 3D co-registration of Cardiovascular Magnetic Resonance (CMR) images to assess the long-term effects of ischemia-reperfusion injury on left ventricular structure after acute ST-elevation myocardial infarction (STEMI). Methods: Forty six patients (age range 3377 years) underwent CMR imaging within 7 days following primary percutaneous coronary intervention (PPCI) for acute STEMI with follow-up at one year. Functional cine imaging and Late Gadolinium Enhancement (LGE) were segmented and co-registered. Local left ventricular wall dilatation was assessed by using intensity-based similarities to track the structural changes in the heart between baseline and follow-up. Results are expressed as means, standard errors and 95% confidence interval (CI) of the difference. Results: Local left ventricular remodeling within infarcted myocardium was greater than in non-infarcted myocardium (1.6% ± 1.0 vs 0.3% ± 0.9, 95% CI: -2.4% -0.2%, P = 0.02). One-way ANOVA revealed that transmural infarct thickness had a significant effect on the degree of local remodeling at one year (P<0.0001) with greatest wall dilatation observed when infarct transmurality exceeded 50%. Infarct remodeling was more severe when microvascular obstruction (MVO) was present (3.8% ± 1.3 vs '1.6% ± 1.4, 95% CI: -9.1% -1.5%, P = 0.007) and when end-diastolic volume had increased by >20% (4.8% ± 1.4 vs '0.15% ± 1.2, 95% CI: -8.9% -0.9%, P = 0.017). Conclusions: The severity of ischemic injury has a significant effect on local ventricular wall remodeling with only modest dilatation observed within non-ischemic myocardium. Limitation of chronic remodeling may therefore depend on therapies directed at modulating ischemia-reperfusion injury. CMR co-registration has potential for assessing dynamic changes in ventricular structure in relation to therapeutic interventions. © 2012 O'Regan et al.; licensee BioMed Central Ltd.
Source Title: Journal of Cardiovascular Magnetic Resonance
URI: http://scholarbank.nus.edu.sg/handle/10635/148917
ISSN: 10976647
DOI: 10.1186/1532-429X-14-41
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
1532-429X-14-41.pdf1 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

14
checked on Jul 3, 2020

WEB OF SCIENCETM
Citations

8
checked on Dec 31, 2018

Page view(s)

114
checked on Jul 3, 2020

Download(s)

17
checked on Jul 3, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.