Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12968-016-0251-4
Title: Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance
Authors: Corden B.
De Marvao A.
Dawes T.J.
Shi W.
Rueckert D.
Cook S.A. 
O'Regan D.P.
Keywords: Body composition
Cardiac atlas
Cardiac remodelling
Cardiovascular magnetic resonance
Obesity
Issue Date: 2016
Publisher: BioMed Central Ltd.
Citation: Corden B., De Marvao A., Dawes T.J., Shi W., Rueckert D., Cook S.A., O'Regan D.P. (2016). Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance 18 (1) : 32. ScholarBank@NUS Repository. https://doi.org/10.1186/s12968-016-0251-4
Abstract: Background: Although obesity is associated with alterations in left ventricular (LV) mass and volume which are of prognostic significance, widely differing patterns of remodelling have been attributed to adiposity. Our aim was to define the relationship between body composition and LV geometry using three-dimensional cardiovascular magnetic resonance. Methods: In an observational study 1530 volunteers (55 % female, mean age 41.3 years) without known cardiovascular disease underwent investigation including breath-hold high spatial resolution 3D cines. Atlas-based segmentation and co-registration was used to create a statistical model of wall thickness (WT) and relative wall thickness (RWT) throughout the LV. The relationship between bio-impedence body composition and LV geometry was assessed using 3D regression models adjusted for age, systolic blood pressure (BP), gender, race and height, with correction to control the false discovery rate. Results: LV mass was positively associated with fat mass in women but not in men (LV mass: women β = 0.11, p < 0.0001; men β = -0.01, p = 0.82). The 3D models revealed that in males fat mass was strongly associated with a concentric increase in relative wall thickness (RWT) throughout most of the LV (β = 0.37, significant area = 96 %) and a reduced mid-ventricular cavity (β = -0.22, significant area = 91 %). In women the regional concentric hypertrophic association was weaker, and the basal lateral wall showed an inverse relationship between RWT and fat mass (β = -0.11, significant area = 4.8 %). Conclusions: In an adult population without known cardiovascular disease increasing body fat is predominately associated with asymmetric concentric hypertrophy independent of systolic BP, with women demonstrating greater cavity dilatation than men. Conventional mass and volume measurements underestimate the impact of body composition on LV structure due to anatomic variation in remodelling. © 2016 The Author(s).
Source Title: Journal of Cardiovascular Magnetic Resonance
URI: http://scholarbank.nus.edu.sg/handle/10635/148910
ISSN: 10976647
DOI: 10.1186/s12968-016-0251-4
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
s12968-016-0251-4.pdf895.72 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

10
checked on Oct 18, 2020

WEB OF SCIENCETM
Citations

3
checked on Dec 24, 2018

Page view(s)

132
checked on Oct 16, 2020

Download(s)

4
checked on Oct 16, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.