Please use this identifier to cite or link to this item:
|Title:||Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson's disease in a Polish population, and a meta-analysis||Authors:||Bia?ecka M.
|Issue Date:||2010||Citation:||Bia?ecka M., Kurzawski M., Tan E.-K., Drozdzik M. (2010). Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson's disease in a Polish population, and a meta-analysis. Neuroscience Letters 472 (1) : 53-55. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2010.01.055||Abstract:||Recently, a variant in LINGO1 (also denominated as LRRN6A) rs9652490:A>G gene has been found to associate with increased risk of essential tremor (ET). Because ET and Parkinson's disease (PD) may be ethiologically related, we proceeded to conduct an analysis of the SNP in PD population. In the current study LINGO1 rs9652490:A>G polymorphism was evaluated in a cohort of 162 Polish patients diagnosed with PD and 177 controls by means of MALDI-TOF mass spectrometry. Any significant differences in rs9652490 genotype or allele frequencies between the studied groups were noted. Our findings demonstrate that LINGO1 SNP (rs9652490) is not associated with sporadic PD in our Polish cohort. A meta-analysis of the available data suggests protective role of rs9652490GG genotype (OR 0.70, 95% CI: 0.51-0.96, p = 0.028). � 2010 Elsevier Ireland Ltd. All rights reserved.||Source Title:||Neuroscience Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/148889||ISSN:||3043940||DOI:||10.1016/j.neulet.2010.01.055|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 4, 2020
WEB OF SCIENCETM
checked on Jul 17, 2019
checked on Jul 3, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.