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Title: Sleep and Parkinson's disease: A review of case-control polysomnography studies
Authors: Peeraully T.
Yong M.-H.
Chokroverty S.
Tan E.-K. 
Keywords: Obstructive sleep apnea
Periodic leg movements
REM behavior disorder
Issue Date: 2012
Citation: Peeraully T., Yong M.-H., Chokroverty S., Tan E.-K. (2012). Sleep and Parkinson's disease: A review of case-control polysomnography studies. Movement Disorders 27 (14) : 1729-1737. ScholarBank@NUS Repository.
Abstract: The link between Parkinson's disease (PD) and certain primary sleep disorders has yet to be clarified. We performed a systematic review of case-control polysomnography studies to evaluate the relationship between PD and sleep disorders. A PubMed literature search and bibliography review yielded 15 case-control polysomnography studies in patients with PD. Studies differed by recruitment methods, duration of polysomnography monitoring, and sleep parameters measured. Subjective sleepiness was greater in patients than controls (50%-66% vs 2.9%-12%) despite lack of objective increase in daytime sleepiness by mean sleep latency testing. The 4 case-control polysomnography studies investigating rapid eye movement behavior disorder support a higher prevalence in PD (0%-47% vs 0%-1.8% in controls), although differences in diagnostic criteria hamper interpretation. The preponderance of evidence did not support an increased incidence of obstructive sleep apnea (27%-60% vs 13%-65%) or periodic leg movements of sleep in patients compared to controls. Adequately powered, prospective studies with uniform methodology and healthy controls are needed to further address the association and pathophysiological significance between PD and sleep problems. � 2012 Movement Disorder Society.
Source Title: Movement Disorders
ISSN: 8853185
DOI: 10.1002/mds.25197
Appears in Collections:Staff Publications

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