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Title: Analysis of a genome-wide association study-linked locus (CCR6) in Asian rheumatoid arthritis
Authors: Teng E.
Leong K.P.
Li H.H.
Thong B.
Koh E.T.
Loi P.L.
Zhao Y.
Tan E.K. 
Issue Date: 2012
Citation: Teng E., Leong K.P., Li H.H., Thong B., Koh E.T., Loi P.L., Zhao Y., Tan E.K. (2012). Analysis of a genome-wide association study-linked locus (CCR6) in Asian rheumatoid arthritis. DNA and Cell Biology 31 (4) : 607-610. ScholarBank@NUS Repository.
Abstract: A genome-wide association study in Japan identified the C-C chemokine receptor type 6 gene (CCR6) as associated with rheumatoid arthritis (RA). This finding has not been validated in other Asian populations. A case-control study involving 996 subjects, comprising 440 controls and 556 RA patients, was done to determine their anticyclic citrullinated peptide (anti-CCP) antibody status and CCR6 polymorphism (rs3093024) genotype. Three hundred eighty-seven patients were anti-CCP positive and 153 anti-CCP negative. Logistic regression showed that allele A was likely to increase the risk of developing RA among females via a recessive model (odds ratio [OR]=1.55, 95% confidence interval [CI]=1.01, 2.39), whereas the risk effect appeared to be reduced among males via an additive model (OR=0.60, 95% CI=0.42, 0.85). Considering only subjects who are anti-CCP positive, allele A increased RA risk among females via a recessive model (OR=1.68, 95% CI=1.07, 2.64) but decreased the risk among males via an additive model (OR=0.59, 95% CI=0.39, 0.89). We showed that CCR6 polymorphism was a risk factor among females but a protective factor among males. Functional studies are warranted to unravel the pathophysiological relevance of the gene variant and other linked variants with RA. © Mary Ann Liebert, Inc.
Source Title: DNA and Cell Biology
ISSN: 10445498
DOI: 10.1089/dna.2011.1350
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