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Title: | Dual functions of AP-1 in neuronal cell death and differentiation | Authors: | LI LEI | Keywords: | AP-1, cell death, cell differentiation, nitric oxide, SH-Sy5y cells, secretogarnin II (SgII) | Issue Date: | 2-Aug-2005 | Citation: | LI LEI (2005-08-02). Dual functions of AP-1 in neuronal cell death and differentiation. ScholarBank@NUS Repository. | Abstract: | Dual functions of AP-1 (c-Jun is a major component of AP-1 dimer) in cell death were discovered by the current study in a single neuroblastoma cell line (SH-Sy5y cells) in response to a single stimulus (NO, nitric oxide): basal c-Jun/AP-1 activity (in the absence of NO stimulation) is important for neuroprotection from NO-caused apoptosis through regulation of the expression of sgII (secretogranin II) and NCAM140 (neural cell adhesion molecule 140); whereas at toxic concentrations of NO, c-Jun is phosphorylated exclusively on Ser-63 in JNK-dependent manner, which enhances c-Jun/AP-1 transcriptional activity, counteracts the protective function of basal AP-1, and eventually leads to apoptosis in SH-Sy5y cells. Besides, AP-1 is also crucial for NGF-induced neuronal differentiation in SH-Sy5y cells, partly through regulating the expression of its target gene sgII and NCAM140. | URI: | http://scholarbank.nus.edu.sg/handle/10635/14836 |
Appears in Collections: | Ph.D Theses (Open) |
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Li Lei PhD thesis - FINAL.pdf | 2.09 MB | Adobe PDF | OPEN | None | View/Download |
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