Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/14812
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dc.titleNovel chiral stationary phase for the enantioseparation of racemic drugs
dc.contributor.authorLO MEE YOON
dc.date.accessioned2010-04-08T10:47:06Z
dc.date.available2010-04-08T10:47:06Z
dc.date.issued2005-07-07
dc.identifier.citationLO MEE YOON (2005-07-07). Novel chiral stationary phase for the enantioseparation of racemic drugs. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/14812
dc.description.abstractThe importance of chirality is attracting more attention from researchers nowadays. Purification of enantiomers is always preferred for safer clinical applications particularly in the biomedical and pharmaceutical areas. Separation of enantiomers is widely studied in high performance liquid chromatography (HPLC) due to its versatility. In this work, series of ether-linkage I?-cyclodextrin (I?-CD) bonded chiral stationary phases (CSPs) were synthesized. The CSPs were perfunctionalized with different substituents and immobilized chemically onto the surface of silica gel via a stable ether-linkage. Six I?-CD bonded CSPs were prepared and characterized. Selected chiral compounds and drugs were evaluated on the CSPs under normal and reversed phase HPLC for the investigation of possible separation mechanisms. Studies of the effects of perfunctionalized substituents and spacer length were carried out. Optimization of the chromatographic conditions was investigated.
dc.language.isoen
dc.subjectbeta-cyclodextrin, chiral stationary phase, ether-linkage, HPLC, spacer length, chromatographic properties
dc.typeThesis
dc.contributor.departmentCHEMISTRY
dc.contributor.supervisorCHAN SZE ON, HARDY
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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