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Title: Novel chiral stationary phase for the enantioseparation of racemic drugs
Authors: LO MEE YOON
Keywords: beta-cyclodextrin, chiral stationary phase, ether-linkage, HPLC, spacer length, chromatographic properties
Issue Date: 7-Jul-2005
Citation: LO MEE YOON (2005-07-07). Novel chiral stationary phase for the enantioseparation of racemic drugs. ScholarBank@NUS Repository.
Abstract: The importance of chirality is attracting more attention from researchers nowadays. Purification of enantiomers is always preferred for safer clinical applications particularly in the biomedical and pharmaceutical areas. Separation of enantiomers is widely studied in high performance liquid chromatography (HPLC) due to its versatility. In this work, series of ether-linkage I?-cyclodextrin (I?-CD) bonded chiral stationary phases (CSPs) were synthesized. The CSPs were perfunctionalized with different substituents and immobilized chemically onto the surface of silica gel via a stable ether-linkage. Six I?-CD bonded CSPs were prepared and characterized. Selected chiral compounds and drugs were evaluated on the CSPs under normal and reversed phase HPLC for the investigation of possible separation mechanisms. Studies of the effects of perfunctionalized substituents and spacer length were carried out. Optimization of the chromatographic conditions was investigated.
Appears in Collections:Ph.D Theses (Open)

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