Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/147496
Title: DETERMINANTS, BIOMARKERS AND IMPACT OF DIABETIC RETINOPATHY IN ASIANS
Authors: GAVIN TAN SIEW WEI
ORCID iD:   orcid.org/0000-0001-5383-7136
Keywords: Diabetic retinopathy, epidemiology, risk factors, biomarkers, asian
Issue Date: 30-Apr-2018
Citation: GAVIN TAN SIEW WEI (2018-04-30). DETERMINANTS, BIOMARKERS AND IMPACT OF DIABETIC RETINOPATHY IN ASIANS. ScholarBank@NUS Repository.
Abstract: The objective of this thesis is to investigate the prevalence, impact, risk factors and ocular determinant of diabetic retinopathy (DR) in a multiethnic Asian population in Singapore. Indians had a higher prevalence of any DR and diabetic macular edema. The major DR risk factors were similar across the 3 ethnic groups, and Indian ethnicity was an independent risk factor for DR. We found in this Asian population that shorter axial length, higher myopia, higher ocular perfusion pressure and wider retinal veins were associated with DR. Increased serum adiponectin and leptin was independently associated with DR. Increased glycated hemoglobin was associated with the incidence and progression DR. The presence of mild DR at baseline increased the risk of progression to referable and vision threatening DR. These non-traditional ocular determinants and blood biomarkers associated with diabetic retinopathy may enable us to better predict the prevalence of diabetic eye disease in Asia.
URI: http://scholarbank.nus.edu.sg/handle/10635/147496
Appears in Collections:Ph.D Theses (Open)

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