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|Title:||Pregnancy trimester-specific exposure to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI||Authors:||Soh S.-E.
|Keywords:||Air pollution; Pre-pregnancy body mass index (BMI); Pregnancy; Respiratory; Trimester||Issue Date:||2018||Publisher:||MDPI AG||Citation:||Soh S.-E., Goh A., Teoh O.H., Godfrey K.M., Gluckman P.D., Shek L.P.-C., Chong Y.-S. (2018). Pregnancy trimester-specific exposure to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI. International Journal of Environmental Research and Public Health 15 (5) : 996. ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph15050996||Abstract:||Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1�4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study (n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2.5 ?m (PM2.5) in the first trimester had an adjusted incidence rate ratio (IRR) (95% confidence interval (CI)) of 1.85 (1.23�2.78), 1.76 (1.08�2.85) and 1.90 (1.10�3.27) in quartile (Q) 2�4, with reference to Q1. This association is seen in the second trimester for bronchiolitis/bronchitis. The risk of ear infection in the first year of life was associated with exposure to PM2.5 in the first trimester with adjusted Odds Ratio (adjOR) (95% CI) = 7.64 (1.18�49.37), 11.37 (1.47�87.97) and 8.26 (1.13�60.29) for Q2�4, and similarly in the second year with adjOR (95% CI) = 3.28 (1.00�10.73) and 4.15 (1.05�16.36) for Q2�3. Prenatal exposure to air pollution has an enhanced impact on childhood respiratory health, and differs according to maternal pre-pregnancy BMI. � 2018 by the authors.||Source Title:||International Journal of Environmental Research and Public Health||URI:||http://scholarbank.nus.edu.sg/handle/10635/147193||ISSN:||16617827||DOI:||10.3390/ijerph15050996|
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