Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41366-018-0032-2
DC Field | Value | |
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dc.title | Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity | |
dc.contributor.author | Tint M.T. | |
dc.contributor.author | Chong M.F. | |
dc.contributor.author | Aris I.M. | |
dc.contributor.author | Godfrey K.M. | |
dc.contributor.author | Quah P.L. | |
dc.contributor.author | Kapur J. | |
dc.contributor.author | Saw S.M. | |
dc.contributor.author | Gluckman P.D. | |
dc.contributor.author | Rajadurai V.S. | |
dc.contributor.author | Yap F. | |
dc.contributor.author | Kramer M.S. | |
dc.contributor.author | Chong Y.-S. | |
dc.contributor.author | Henry C.J. | |
dc.contributor.author | Fortier M.V. | |
dc.contributor.author | Lee Y.S. | |
dc.date.accessioned | 2018-09-12T01:14:31Z | |
dc.date.available | 2018-09-12T01:14:31Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Tint M.T., Chong M.F., Aris I.M., Godfrey K.M., Quah P.L., Kapur J., Saw S.M., Gluckman P.D., Rajadurai V.S., Yap F., Kramer M.S., Chong Y.-S., Henry C.J., Fortier M.V., Lee Y.S. (2018). Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity. International Journal of Obesity 42 (7) : 1296-1305. ScholarBank@NUS Repository. https://doi.org/10.1038/s41366-018-0032-2 | |
dc.identifier.issn | 03070565 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/147186 | |
dc.description.abstract | Objectives: Lower vitamin D status has been associated with adiposity in children through adults. However, the evidence of the impact of maternal vitamin-D status during pregnancy on offspring�s adiposity is mixed. The objective of this study was to examine the associations between maternal vitamin-D [25(OH)D] status at mid-gestation and neonatal abdominal adipose tissue (AAT) compartments, particularly the deep subcutaneous adipose tissue linked with metabolic risk. Methods: Participants (N = 292) were Asian mother-neonate pairs from the mother-offspring cohort, Growing Up in Singapore Towards healthy Outcomes. Neonates born at ?34 weeks gestation with birth weight ?2000 g had magnetic resonance imaging (MRI) within 2-weeks post-delivery. Maternal plasma glucose using an oral glucose tolerance test and 25(OH)D concentrations were measured. 25(OH)D status was categorized into inadequate (?75.0 nmol/L) and sufficient (>75.0 nmol/L) groups. Neonatal AAT was classified into superficial (sSAT), deep subcutaneous (dSAT), and internal (IAT) adipose tissue compartments. Results: Inverse linear correlations were observed between maternal 25(OH)D and both sSAT (r = ?0.190, P = 0.001) and dSAT (r = ?0.206, P < 0.001). Each 1 nmol/L increase in 25(OH)D was significantly associated with reductions in sSAT (? = ?0.14 (95% CI: ?0.24, ?0.04) ml, P = 0.006) and dSAT (? = ?0.04 (?0.06, ?0.01) ml, P = 0.006). Compared to neonates of mothers with 25(OH)D sufficiency, neonates with maternal 25(OH)D inadequacy had higher sSAT (7.3 (2.1, 12.4) ml, P = 0.006), and dSAT (2.0 (0.6, 3.4) ml, P = 0.005) volumes, despite similar birth weight. In the subset of mothers without gestational diabetes, neonatal dSAT was also greater (1.7 (0.3, 3.1) ml, P = 0.019) in neonates with maternal 25(OH)-inadequacy. The associations with sSAT and dSAT persisted even after accounting for maternal glycemia (fasting and 2-h plasma glucose). Conclusions: Neonates of Asian mothers with mid-gestation 25(OH)D inadequacy have a higher abdominal subcutaneous adipose tissue volume, especially dSAT (which is metabolically similar to visceral adipose tissue in adults), even after accounting for maternal glucose levels in pregnancy. � 2018, The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | DEPT OF BIOCHEMISTRY | |
dc.contributor.department | DEPT OF DIAGNOSTIC RADIOLOGY | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.contributor.department | DEPT OF PAEDIATRICS | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1038/s41366-018-0032-2 | |
dc.description.sourcetitle | International Journal of Obesity | |
dc.description.volume | 42 | |
dc.description.issue | 7 | |
dc.description.page | 1296-1305 | |
dc.description.coden | IJOBD | |
dc.description.series | GUSTO (Growing up towards Healthy Outcomes) | |
dc.published.state | Published | |
dc.grant.id | NMRC/TCR/004-NUS/2008 | |
dc.grant.id | NMRC/TCR/012-NUHS/2014 | |
dc.grant.fundingagency | SICS, Singapore Institute for Clinical Sciences | |
dc.grant.fundingagency | FP7, Seventh Framework Programme | |
dc.grant.fundingagency | NRF, National Research Foundation Singapore | |
dc.grant.fundingagency | NMRC, National Medical Research Council | |
dc.grant.fundingagency | NIHR, National Institute for Health Research | |
dc.grant.fundingagency | NIHR, National Institute for Health Rese | |
Appears in Collections: | Elements Staff Publications |
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