Please use this identifier to cite or link to this item:
Title: Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity
Authors: Tint M.T. 
Chong M.F. 
Aris I.M.
Godfrey K.M.
Quah P.L. 
Kapur J. 
Saw S.M. 
Gluckman P.D. 
Rajadurai V.S. 
Yap F. 
Kramer M.S. 
Chong Y.-S. 
Henry C.J. 
Fortier M.V. 
Lee Y.S. 
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Tint M.T., Chong M.F., Aris I.M., Godfrey K.M., Quah P.L., Kapur J., Saw S.M., Gluckman P.D., Rajadurai V.S., Yap F., Kramer M.S., Chong Y.-S., Henry C.J., Fortier M.V., Lee Y.S. (2018). Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity. International Journal of Obesity 42 (7) : 1296-1305. ScholarBank@NUS Repository.
Abstract: Objectives: Lower vitamin D status has been associated with adiposity in children through adults. However, the evidence of the impact of maternal vitamin-D status during pregnancy on offspring�s adiposity is mixed. The objective of this study was to examine the associations between maternal vitamin-D [25(OH)D] status at mid-gestation and neonatal abdominal adipose tissue (AAT) compartments, particularly the deep subcutaneous adipose tissue linked with metabolic risk. Methods: Participants (N = 292) were Asian mother-neonate pairs from the mother-offspring cohort, Growing Up in Singapore Towards healthy Outcomes. Neonates born at ?34 weeks gestation with birth weight ?2000 g had magnetic resonance imaging (MRI) within 2-weeks post-delivery. Maternal plasma glucose using an oral glucose tolerance test and 25(OH)D concentrations were measured. 25(OH)D status was categorized into inadequate (?75.0 nmol/L) and sufficient (>75.0 nmol/L) groups. Neonatal AAT was classified into superficial (sSAT), deep subcutaneous (dSAT), and internal (IAT) adipose tissue compartments. Results: Inverse linear correlations were observed between maternal 25(OH)D and both sSAT (r = ?0.190, P = 0.001) and dSAT (r = ?0.206, P < 0.001). Each 1 nmol/L increase in 25(OH)D was significantly associated with reductions in sSAT (? = ?0.14 (95% CI: ?0.24, ?0.04) ml, P = 0.006) and dSAT (? = ?0.04 (?0.06, ?0.01) ml, P = 0.006). Compared to neonates of mothers with 25(OH)D sufficiency, neonates with maternal 25(OH)D inadequacy had higher sSAT (7.3 (2.1, 12.4) ml, P = 0.006), and dSAT (2.0 (0.6, 3.4) ml, P = 0.005) volumes, despite similar birth weight. In the subset of mothers without gestational diabetes, neonatal dSAT was also greater (1.7 (0.3, 3.1) ml, P = 0.019) in neonates with maternal 25(OH)-inadequacy. The associations with sSAT and dSAT persisted even after accounting for maternal glycemia (fasting and 2-h plasma glucose). Conclusions: Neonates of Asian mothers with mid-gestation 25(OH)D inadequacy have a higher abdominal subcutaneous adipose tissue volume, especially dSAT (which is metabolically similar to visceral adipose tissue in adults), even after accounting for maternal glucose levels in pregnancy. � 2018, The Author(s).
Source Title: International Journal of Obesity
ISSN: 03070565
DOI: 10.1038/s41366-018-0032-2
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
(175).pdf592.72 kBAdobe PDF


NoneLog In

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.