Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/147044
Title: CYSTEINE DEPRIVATION AS A POTENTIAL THERAPEUTIC MODALITY FOR OVARIAN CARCINOMA
Authors: WISNA NOVERA
Keywords: Cysteine, cystathionase, system Xc-, oxidative stress, iron-sulfur cluster, mitochondria
Issue Date: 3-May-2018
Citation: WISNA NOVERA (2018-05-03). CYSTEINE DEPRIVATION AS A POTENTIAL THERAPEUTIC MODALITY FOR OVARIAN CARCINOMA. ScholarBank@NUS Repository.
Abstract: Cysteine is a non-essential amino acid well known for its anti-oxidative property. Despite oxidative stress being an ever-present phenomenon in cancer, there are rather limited studies that assess the importance of cysteine amino acid in cancers. The current study aimed to examine the importance of cysteine amino acid, using ovarian clear cell carcinoma (OCCC) as the cancer model. OCCC expresses high cystathionase (CTH), the enzyme responsible for endogenous cysteine synthesis. It was therefore hypothesized that OCCC requires cysteine for survival. In accordance, independent individual amino acid starvation showed cysteine deprivation exert the most prominent cytotoxicity, even exceeded that caused by withdrawal of other amino acids, including the essential ones. Using pharmacologically induced cysteine deprivation, the study demonstrated its therapeutic anti-cancer applications and dissected the underlying mechanisms responsible for its cytotoxicity. The study showcased cysteine roles in cancer beyond its anti-oxidative function.
URI: http://scholarbank.nus.edu.sg/handle/10635/147044
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
NoveraW.pdf4.38 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

251
checked on Nov 24, 2022

Download(s)

22
checked on Nov 24, 2022

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.