Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-01540-7
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dc.titleRisk of death from cardiovascular disease following breast cancer in Southeast Asia: A prospective cohort study
dc.contributor.authorGernaat S.A.M.
dc.contributor.authorHo P.J.
dc.contributor.authorRijnberg N.
dc.contributor.authorLee S.C.
dc.contributor.authorLim S.H.
dc.contributor.authorYap Y.S.
dc.contributor.authorGrobbee D.E.
dc.contributor.authorHartman M.
dc.contributor.authorVerkooijen H.M.
dc.date.accessioned2018-08-29T08:53:32Z
dc.date.available2018-08-29T08:53:32Z
dc.date.issued2017-05-02
dc.identifier.citationGernaat S.A.M., Ho P.J., Rijnberg N., Lee S.C., Lim S.H., Yap Y.S., Grobbee D.E., Hartman M., Verkooijen H.M. (2017-05-02). Risk of death from cardiovascular disease following breast cancer in Southeast Asia: A prospective cohort study. Scientific Reports 7 (1) : 1365. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-01540-7
dc.identifier.issn20452322
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/146670
dc.description.abstractBreast cancer incidence and survival is high in Southeast Asia. As such, many women diagnosed with breast cancer are at risk of dying of other causes. Given the increased risk of cardiotoxicity induced by breast cancer treatments, it is important to identify patients at high risk of cardiovascular disease (CVD) mortality. The aim of this study was to investigate if this risk varies by age and ethnicity. Patient details were obtained from 5,868 Chinese, Malay, and Indian women diagnosed with in situ or non-metastasized invasive breast cancer at the National University Hospital of Singapore and KK Women's and Children's Hospital in Singapore. Death causes were obtained from the National Registry of Births and Deaths. Flexible parametric survival models estimated CVD mortality rates and hazard ratios. During a median follow-up of six years, 1,010 deaths occurred of which 6.8% were due to CVD. CVD mortality rates of older women peaked within the first year following diagnosis and increased over time since diagnosis. Indian had more than double the risk of CVD mortality than Chinese, independent of age at diagnosis and stage. Taking ethnicity and age into account may promote CVD risk stratification and management in (Southeast Asian) women with breast cancer. � 2017 The Author(s).
dc.publisherNature Publishing Group
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.1038/s41598-017-01540-7
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.issue1
dc.description.page1365
dc.published.statepublished
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