Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/146644
Title: BIODEGRADABLE POLYMERIC MICELLES AS DRUG CARRIERS TO TARGET CANCER CELLS AND CANCER STEM CELLS
Authors: SANGEETHA SWARNA LAKSHMI KRISHNAMURTHY
Keywords: Nanoparticles, polymeric, cancer stem cells, drug delivery
Issue Date: 11-Aug-2014
Citation: SANGEETHA SWARNA LAKSHMI KRISHNAMURTHY (2014-08-11). BIODEGRADABLE POLYMERIC MICELLES AS DRUG CARRIERS TO TARGET CANCER CELLS AND CANCER STEM CELLS. ScholarBank@NUS Repository.
Abstract: CANCER IS ONE OF THE MOST UNCONQUERABLE DISEASES AND CANCER STEM CELLS (CSCS) ARE OFTEN IMPLICATED IN TREATMENT FAILURE. EFFECTIVE CHEMOTHERAPEUTIC REGIMEN THAT TARGETS THE HETEROGENEOUS POPULATION INCLUDING CSCS IN A CANCER IS NECESSARY WITH TOLERABLE TOXICITY PROFILES TO ACHIEVE TREATMENT SUCCESS. IN THIS THESIS, NANOSIZED MICELLES (M) FORMED BY SELF-ASSEMBLY OF PEG-POLYCARBONATE AMPHIPHILIC DIBLOCK COPOLYMERS WERE EMPLOYED TO DELIVER THE DRUGS ? GEMCITABINE (GEM), DOXORUBICIN (DOX) AND PHENFORMIN (PHEN), INDIVIDUALLY. H460 LUNG CANCER CELL LINE WAS USED AS THE IN VITRO AND ITS SUBCUTANEOUS MOUSE XENOGRAFTS AS IN VIVO CANCER MODELS. GEM-LOADED MICELLES (GEMM) INHIBITED CANCER CELLS BETTER THAN DOX-LOADED MICELLES, BUT HAD NO EFFECT ON CSCS WHILE PHENFORMIN-LOADED MICELLES (PHENM) INHIBITED CSCS AND THEIR ABILITY TO MIGRATE AND INVADE IN VITRO. PHENM ALSO SHOWED SUPERIOR ANTI-TUMOR EFFECT IN VIVO THAN FREE PHENFORMIN. A REDUCED PHENM DOSAGE USED IN COMBINATION WITH GEMM SHOWED HIGHER
URI: http://scholarbank.nus.edu.sg/handle/10635/146644
Appears in Collections:Ph.D Theses (Open)

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