Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/146643
Title: MICRO AND NANOSCALE FORMULATIONS FOR DRUG ABSORPTION THROUGH SKIN
Authors: HIMANSHU KATHURIA
ORCID iD:   orcid.org/0000-0002-9502-2901
Keywords: Microneedle, Nanoformulation, Proposomes, Targeted delivery, Skin Formulation, Microneedle dissolution
Issue Date: 23-Jan-2018
Citation: HIMANSHU KATHURIA (2018-01-23). MICRO AND NANOSCALE FORMULATIONS FOR DRUG ABSORPTION THROUGH SKIN. ScholarBank@NUS Repository.
Abstract: Transdermal drug delivery offers an appealing alternative for administration of drugs. However, most of the current topical treatments show slow onset of action resulted from limited and slow drug permeation through skin. The microneedle (MN) and liposomes in this regard can help to increase the skin permeation but most of the current formulation methods involve harsh conditions, complex, long and multiple steps, and the targeted drug delivery to the various skin layers remains a challenge. In this thesis, we develop the fast fabrication approaches to prepare MN patches, which were capable for better skin delivery, overcomes the issue of instability of therapeutics and scale-up. We have also shown the simple approach to prepare nanoscale liposomal formulation for targeted drug delivery into various skin layers, which is safe, free from toxic solvents and patient friendly. Overall, the micro and nanoscale formulation were safe and efficacious for potential skin applications.
URI: http://scholarbank.nus.edu.sg/handle/10635/146643
Appears in Collections:Ph.D Theses (Open)

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