Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/145061
Title: COMPLEMENT ACTIVATION BY GOLD NANOPARTICLES: MECHANISM AND APPLICATION
Authors: QUACH QUANG HUY
ORCID iD:   orcid.org/0000-0003-2191-5771
Keywords: gold nanoparticles, PEGylation, complement activation, dengue vaccine, subunit vaccine, complement system
Issue Date: 24-Jan-2018
Citation: QUACH QUANG HUY (2018-01-24). COMPLEMENT ACTIVATION BY GOLD NANOPARTICLES: MECHANISM AND APPLICATION. ScholarBank@NUS Repository.
Abstract: The complement system is a key humoral component of innate immunity, serving as the first line of defense and exerting its functional effects on adaptive immunity upon being activated. Recently, activation of the complement system is emerging as an indicator of biocompatibility of nanomaterials in the context of increasing use of nanomaterials in biomedical applications. Gold nanoparticles are widely used in biomedical applications, but its interactions with the complement system remain poorly understood. This thesis was initiated to investigate the mechanism of complement activation by a library of gold nanoparticles of different sizes, shapes as well as surface chemistries. It was found that this library activated the complement system differently. While this finding highlighted the adverse effects of gold nanoparticles used as delivery platforms, it was successfully exploited for the development of subunit vaccine against dengue virus in this study.
URI: http://scholarbank.nus.edu.sg/handle/10635/145061
Appears in Collections:Ph.D Theses (Open)

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