Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/144361
Title: STUDY OF LOW SUBSTRATE ELASTICITY ON BIOFILM REDUCTION FOR BIOMEDICAL APPLICATIONS
Authors: LEE YEONG YUH
Keywords: biofilm, elastic modulus, soft material, silicone elastomers, biomedical devices, anti-fouling
Issue Date: 14-Aug-2015
Citation: LEE YEONG YUH (2015-08-14). STUDY OF LOW SUBSTRATE ELASTICITY ON BIOFILM REDUCTION FOR BIOMEDICAL APPLICATIONS. ScholarBank@NUS Repository.
Abstract: THE EFFECTS OF DIFFERENCES IN THE ELASTIC MODULUS OF MATERIALS ON SHORT-TERM BACTERIAL ADHESION AND LONG-TERM BIOFILM DEVELOPMENT WERE INVESTIGATED. POLYDIMETHYLSILOXANE WITH TUNABLE ELASTIC MODULUS OVER THREE ORDERS OF MAGNITUDE WERE USED IN THIS STUDY. INVESTIGATIONS INDICATE THAT REDUCTIONS IN BACTERIA QUANTITIES WERE OBSERVED NOT ONLY AT THE INITIAL STAGES OF BACTERIA COLONIZATION BUT ALSO AT LATER STAGES OF BIOFILM DEVELOPMENT. EXOPOLYSACCHARIDE COMPONENTS WERE FOUND TO BE REDUCED IN E. COLI BIOFILMS GROWN ON SOFT SUBSTRATES WHICH SUGGESTED THAT LOW SUBSTRATE ELASTICITY AFFECTS BIOFILM FORMATION THROUGH THE REGULATION OF EPS COMPONENTS. THE SOFT SILICONE ELASTOMER WAS FURTHER APPLIED AS AN INNER COATING ON URINARY CATHETERS AND EVALUATED AT SHORT-TERM CATHETERIZATION CONDITIONS. OUR RESULTS SHOW THAT THE SOFT SILICONE SURFACES DID NOT SHOW SIGNIFICANT IMPROVEMENT IN BIOFILM REDUCTION. HOWEVER, P. MIRABILIS ENCRUSTATION WAS REDUCED ON SOFT SILICONE SURFACES WHICH MAY SUGGEST THAT L
URI: http://scholarbank.nus.edu.sg/handle/10635/144361
Appears in Collections:Ph.D Theses (Open)

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