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|Title:||ROLE OF THE CIRCADIAN RHYTHM IN OVARIAN FUNCTION||Authors:||LIM JUE RU AUDREY||Keywords:||Polycystic Ovary Syndrome, Circadian Rhythm, Chronodisruption, Clock Genes, Steroidogenesis, Anovulation||Issue Date:||1-Dec-2017||Citation:||LIM JUE RU AUDREY (2017-12-01). ROLE OF THE CIRCADIAN RHYTHM IN OVARIAN FUNCTION. ScholarBank@NUS Repository.||Abstract:||In this thesis, we aimed to explore the role of circadian rhythms in ovarian function, and in particular, the main question we sought to address was whether chronodisruption leads to PCOS. Results from two population studies and an animal study led us to conclude that chronodisruption does not lead to PCOS, but may instead induce a state of anovulation resembling hypothalamic amenorrhea. However, increasing severity of PCOS may lead to increased morning melatonin and cortisol levels, suggestive of an increased risk of disrupted circadian rhythms and stress. Additionally, in chronodisrupted rats exposed to continuous light, we prevent novel findings of disrupted mRNA expression rhythms of key ovarian clock genes, confirming that photic changes disrupt ovarian pacemaker genes. Our results also suggest that deficiency of the core clock gene, BMAL1, may mechanistically reduce steroidogenesis via circadian disruption of StAR gene expression.||URI:||http://scholarbank.nus.edu.sg/handle/10635/142302|
|Appears in Collections:||Ph.D Theses (Open)|
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