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|Title:||MOLECULAR MICROBIOLOGY OF BACTERIAL-FUNGAL MIXED-SPECIES BIOFILMS AND CLINICAL IMPLICATIONS||Authors:||KASSAPA JAYO BANDARA ELLEPOLA||ORCID iD:||orcid.org/0000-0003-3806-9807||Keywords:||Candida albicans, Streptococcus mutans, Pseudomonas aeruginosa, Biofilms, Glucosyltransferase, Dental caries||Issue Date:||17-Jan-2018||Citation:||KASSAPA JAYO BANDARA ELLEPOLA (2018-01-17). MOLECULAR MICROBIOLOGY OF BACTERIAL-FUNGAL MIXED-SPECIES BIOFILMS AND CLINICAL IMPLICATIONS. ScholarBank@NUS Repository.||Abstract:||Candida albicans is a major fungal pathogen in humans. C. albicans forms mixed-species biofilms with bacterial counterparts in various infectious diseases. The work presented in this thesis aimed to understand the molecular mechanisms governing the inter-kingdom biofilms and their clinical implications. Comprehensive OMICS biology approaches such as transcriptomics and proteomics techniques were employed to unravel the molecular pathways involved in these mixed-species biofilms. C. albicans and Streptococcus mutans mixed-species biofilms were studied as a fungal-gram positive bacterial model. S. mutans derived exoenzyme “glucosyltransferase B” (GtfB) was found to augment C. albicans in mixed-species biofilms, explaining its role in the development of early childhood caries. Frequently found in cystic fibrosis patients, C. albicans-Pseudomonas aeruginosa mixed-species biofilms were used as a model system for fungal-gram negative bacterial interactions. P. aeruginosa was able to inhibit C. albicans and the underlying molecular mechanisms revealed relevant information on enhanced virulence of these organisms in mixed-biofilms.||URI:||http://scholarbank.nus.edu.sg/handle/10635/142122|
|Appears in Collections:||Ph.D Theses (Open)|
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